Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases

Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases

Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for...

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Main Author: Aline Yen Ling Wang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
induced pluripotent stem cells
exosome
cell-free regenerative medicine
Online Access:https://www.mdpi.com/1422-0067/22/4/1769
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spelling doaj-b75bbcbe899d40e6a5209eed1624e3472021-02-11T00:05:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01221769176910.3390/ijms22041769Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various DiseasesAline Yen Ling Wang0Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, 5 Fu-hsing Street, Gueishan, Taoyuan 333, TaiwanRecently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration.https://www.mdpi.com/1422-0067/22/4/1769induced pluripotent stem cellsexosomecell-free regenerative medicine
collection DOAJ
language English
format Article
sources DOAJ
author Aline Yen Ling Wang
spellingShingle Aline Yen Ling Wang
Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
International Journal of Molecular Sciences
induced pluripotent stem cells
exosome
cell-free regenerative medicine
author_facet Aline Yen Ling Wang
author_sort Aline Yen Ling Wang
title Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
title_short Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
title_full Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
title_fullStr Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
title_full_unstemmed Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases
title_sort human induced pluripotent stem cell-derived exosomes as a new therapeutic strategy for various diseases
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-02-01
description Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration.
topic induced pluripotent stem cells
exosome
cell-free regenerative medicine
url https://www.mdpi.com/1422-0067/22/4/1769
work_keys_str_mv AT alineyenlingwang humaninducedpluripotentstemcellderivedexosomesasanewtherapeuticstrategyforvariousdiseases
_version_ 1724274774246424576

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