The triglyceride lipases of the pancreas

The triglyceride lipases of the pancreas

Pancreatic triglyceride lipase (P33333344) and its protein cofactor, colipase, are required for efficient dietary triglyceride digestion. In addition to PTL, pancreatic acinar cells synthesize two pancreatic lipase related proteins (PLRP1 and PLRP2), which have a high degree of sequence and structur...

Full description

Bibliographic Details
Main Author:	Mark E. Lowe
Format:	Article
Language:	English
Published:	Elsevier 2002-12-01
Series:	Journal of Lipid Research
Subjects:	triglyceride X-ray crystal structure C2-domain colipase site directed mutagenesis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520327267

Similar Items

The open lid mediates pancreatic lipase function
by: Yanqing Yang, et al.
Published: (2000-01-01)

Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion
by: Xunjun Xiao, et al.
Published: (2011-05-01)

Using Lipase to Improve the Functional Properties of Yolk-Contaminated Egg Whites
by: Macherey, Laura Nicole
Published: (2014)

Structure-function relationship study of a loop structure in allosteric behaviour and substrate inhibition of <i>Lactococcus lactis</i> prolidase
by: Chen, Jian An
Published: (2011)

Substrate pathways and mechanisms of inhibition in the sulfur oxygenase reductase of Acidianus ambivalens
by: Andreas eVeith, et al.
Published: (2011-03-01)

The hydrophobic surface of colipase influences lipase activity at an oil–water interface
by: Richard A. Cordle, et al.
Published: (1998-09-01)

Structural Studies of Prokaryotic and Eukaryotic Oligoribonucleases
by: Nelersa, Claudiu M.
Published: (2009)

Exploring the ATP-binding site of P2X receptors
by: Thierry eChataigneau, et al.
Published: (2013-12-01)

Directed Evolution of Pseudomonas fluorescens Lipase Variants With Improved Thermostability Using Error-Prone PCR
by: Lijun Guan, et al.
Published: (2020-09-01)

Corrigendum: Directed Evolution of Pseudomonas fluorescens Lipase Variants With Improved Thermostability Using Error-Prone PCR
by: Lijun Guan, et al.
Published: (2020-10-01)

The physicochemical characteristics of the Longissimus lumborum muscle of crossbred pigs in relation to the CLPS and RYR1 genes polymorphism
by: Hanna JANKOWIAK, et al.
Published: (2016-09-01)

Biotechnology of Cold-Active Proteases
by: Tulasi Satyanarayana, et al.
Published: (2013-05-01)

SLAUGHTER VALUE OF PIGS CARCASSES AS RELATED TO COLIPASE GENOTYPE (CLPS) CONSIDERING RYR1 GENE EFFECT
by: Hanna JANKOWIAK, et al.
Published: (2009-06-01)

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase
by: John G. Luz, et al.
Published: (2020-10-01)

Characterization of lysosomal acid lipase mutations in the signal peptide and mature polypeptide region causing Wolman disease
by: Oliver Zschenker, et al.
Published: (2001-07-01)

Enhancement of a protocol purifying T1 lipase through molecular approach
by: Che Haznie Ayu Che Hussian, et al.
Published: (2018-11-01)

Exciton transfer and trapping in photosystem II
by: Merry, Stephen Alan Paul
Published: (1998)

Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo
by: Robert J. Brown, et al.
Published: (2007-05-01)

Biochemical and structural analysis of a site directed mutant of manganese dependent aminopeptidase P from Streptomyces lavendulae
by: ARYA NANDAN, et al.
Published: (2015-08-01)

Altered sugar donor specificity and catalytic activity of pteridine glycosyltransferases by domain swapping or site-directed mutagenesis
by: Hye-Lim Kim, et al.
Published: (2013-01-01)

Residue Asn277 Affects the Stability and Substrate Specificity of the SMG1 Lipase from Malassezia globosa
by: Dongming Lan, et al.
Published: (2015-03-01)

The structural basis for the catalytic specificity of manganese lipoxygenases : 3D structure analysis of the lipoxygenase of Magnaporthe oryzae
by: Wennman, Anneli
Published: (2015)

Mechanistic Studies of the Roles of the Transcriptional Activator ExsA and Anti-activator Protein ExsD in the Regulation of the Type Three Secretion System in Pseudomonas aeruginosa
by: Shrestha, Manisha
Published: (2019)

Structural Basis of RICs Iron Donation for Iron-Sulfur Cluster Biogenesis
by: Liliana S. O. Silva, et al.
Published: (2021-04-01)

Investigation of the role of the ubiquitin-like DWNN domain in targeting Retinoblastoma Binding Protein 6 to nuclear speckles
by: Mlaza, Mihlali
Published: (2018)

Restriction digest screening facilitates efficient detection of site-directed mutations introduced by CRISPR in C. albicans UME6
by: Ben A. Evans, et al.
Published: (2018-06-01)

Conserved Residues in the C-Terminal Domain Affect the Structure and Function of CYP38 in Arabidopsis
by: Lujing Shi, et al.
Published: (2021-02-01)

A novel cold-adapted esterase from Enterobacter cloacae: Characterization and improvement of its activity and thermostability via the site of Tyr193Cys
by: Haofeng Gao, et al.
Published: (2018-03-01)

Endothelial lipase is inactivated upon cleavage by the members of the proprotein convertase family
by: Martin Gauster, et al.
Published: (2005-05-01)

Improving the Thermostability of Rhizopus chinensis Lipase Through Site-Directed Mutagenesis Based on B-Factor Analysis
by: Zhanbao Jiang, et al.
Published: (2020-03-01)

Expression and Mutagenesis studies of Candida antactica lipase B
by: Rotticci-Mulder, Johanna C.
Published: (2003)

The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity
by: Li-Ming Dong, et al.
Published: (1998-06-01)

Enzymatic Properties and Mutational Studies of Chalcone Synthase from <em>Physcomitrella patens</em>
by: Mahiran Basri, et al.
Published: (2012-08-01)

Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase
by: Shi-Qin Xiang, et al.
Published: (1999-09-01)

OneClick: A Program for Designing Focused Mutagenesis Experiments
by: Mark Warburton, et al.
Published: (2015-07-01)

Preferential Protection of Domains II and III of Bacillus thuringiensis Cry1Aa Toxin by Brush Border Membrane Vesicles
by: Syed-Rehan A. Hussain, et al.
Published: (2010-07-01)

Preferential Protection of Domains II and III of Bacillus thuringiensis Cry1Aa Toxin by Brush Border Membrane Vesicles
by: Syed-Rehan A. Hussain, et al.
Published: (2011-01-01)

The local structure around Ge atoms in Ge-doped magnetite thin films
by: Shinoda Kozo, et al.
Published: (2020-12-01)

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R
by: Cecilia Pozzi, et al.
Published: (2019-04-01)

Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme
by: Miki Hiraoka, et al.
Published: (2013-11-01)