The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus.
Amyloid plaque has been reported in brain biopsies from patients with idiopathic normal-pressure hydrocephalus (iNPH) and proposed as a significant feature of the pathophysiology. Presence of the apolipoprotein E ε4 (APOE ε4) allele is associated with increased risk of Alzheimer's disease (AD)....
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doaj-b767aeda7d0e4cacad18767417bdd3272020-11-25T00:44:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01117e015898510.1371/journal.pone.0158985The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus.Yi YangMats TullbergKirsten MehligAnnika RosengrenKjell TorénHenrik ZetterbergCarsten WikkelsöAmyloid plaque has been reported in brain biopsies from patients with idiopathic normal-pressure hydrocephalus (iNPH) and proposed as a significant feature of the pathophysiology. Presence of the apolipoprotein E ε4 (APOE ε4) allele is associated with increased risk of Alzheimer's disease (AD).To compare the distribution of APOE genotype in iNPH patients with an age-matched population-based control group and with Alzheimer's disease (AD) patients.APOE genotype frequencies were determined in 77 iNPH patients (50 men and 27 women, mean age 71.7 years) diagnosed with iNPH, a sample of 691 AD patients and 638 age-matched population controls (299 men and 339 women) from the INTERGENE cohort.The APOE distribution did not differ significantly between the iNPH patients and the control population. The per e4-allele odds-ratio (OR) of iNPH was given by OR = 0.90, 95% confidence interval (CI) = (0.50, 1.60) that was considerably smaller than the per-allele OR of AD, OR = 5.34 (4.10, 7.00).The results suggest that the APOE-related risk of AD in patients with iNPH is not higher than in the general population.http://europepmc.org/articles/PMC4956274?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi Yang Mats Tullberg Kirsten Mehlig Annika Rosengren Kjell Torén Henrik Zetterberg Carsten Wikkelsö |
spellingShingle |
Yi Yang Mats Tullberg Kirsten Mehlig Annika Rosengren Kjell Torén Henrik Zetterberg Carsten Wikkelsö The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus. PLoS ONE |
author_facet |
Yi Yang Mats Tullberg Kirsten Mehlig Annika Rosengren Kjell Torén Henrik Zetterberg Carsten Wikkelsö |
author_sort |
Yi Yang |
title |
The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus. |
title_short |
The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus. |
title_full |
The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus. |
title_fullStr |
The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus. |
title_full_unstemmed |
The APOE Genotype in Idiopathic Normal Pressure Hydrocephalus. |
title_sort |
apoe genotype in idiopathic normal pressure hydrocephalus. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Amyloid plaque has been reported in brain biopsies from patients with idiopathic normal-pressure hydrocephalus (iNPH) and proposed as a significant feature of the pathophysiology. Presence of the apolipoprotein E ε4 (APOE ε4) allele is associated with increased risk of Alzheimer's disease (AD).To compare the distribution of APOE genotype in iNPH patients with an age-matched population-based control group and with Alzheimer's disease (AD) patients.APOE genotype frequencies were determined in 77 iNPH patients (50 men and 27 women, mean age 71.7 years) diagnosed with iNPH, a sample of 691 AD patients and 638 age-matched population controls (299 men and 339 women) from the INTERGENE cohort.The APOE distribution did not differ significantly between the iNPH patients and the control population. The per e4-allele odds-ratio (OR) of iNPH was given by OR = 0.90, 95% confidence interval (CI) = (0.50, 1.60) that was considerably smaller than the per-allele OR of AD, OR = 5.34 (4.10, 7.00).The results suggest that the APOE-related risk of AD in patients with iNPH is not higher than in the general population. |
url |
http://europepmc.org/articles/PMC4956274?pdf=render |
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