Pharmacologic therapy for inflammatory bowel disease refractory to steroids
MP Martínez-Montiel, B Casis-Herce , GJ Gómez-Gómez, A Masedo-González, C Yela-San Bernardino, C Piedracoba, G Castellano-Tortajada Division of Gastroenterology, Hospital 12 de Octubre, Madrid, SpainAbstract: Although corticosteroids are an effective treat...
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2015-08-01
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doaj-b7727738cdbf4e25bf7e727af0747c012020-11-24T20:56:20ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232015-08-012015default25726923175Pharmacologic therapy for inflammatory bowel disease refractory to steroidsMartínez-Montiel MPCasis-Herce BGómez-Gómez GJMasedo-González AYela-San Bernardino CPiedracoba CCastellano-Tortajada GMP Martínez-Montiel, B Casis-Herce , GJ Gómez-Gómez, A Masedo-González, C Yela-San Bernardino, C Piedracoba, G Castellano-Tortajada Division of Gastroenterology, Hospital 12 de Octubre, Madrid, SpainAbstract: Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, and Cochrane reviews on the management of IBD refractory to corticosteroids. Based on this evidence, we propose algorithms and optimization strategies for use of immunomodulator and biologic therapy in IBD refractory to corticosteroids.Keywords: immunomodulators, anti-tumor necrosis factor alpha, Crohn's disease, ulcerative colitis, drug levels, treatment optimizationhttp://www.dovepress.com/pharmacologic-therapy-for-inflammatory-bowel-disease-refractory-to-ste-peer-reviewed-article-CEG |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martínez-Montiel MP Casis-Herce B Gómez-Gómez GJ Masedo-González A Yela-San Bernardino C Piedracoba C Castellano-Tortajada G |
spellingShingle |
Martínez-Montiel MP Casis-Herce B Gómez-Gómez GJ Masedo-González A Yela-San Bernardino C Piedracoba C Castellano-Tortajada G Pharmacologic therapy for inflammatory bowel disease refractory to steroids Clinical and Experimental Gastroenterology |
author_facet |
Martínez-Montiel MP Casis-Herce B Gómez-Gómez GJ Masedo-González A Yela-San Bernardino C Piedracoba C Castellano-Tortajada G |
author_sort |
Martínez-Montiel MP |
title |
Pharmacologic therapy for inflammatory bowel disease refractory to steroids |
title_short |
Pharmacologic therapy for inflammatory bowel disease refractory to steroids |
title_full |
Pharmacologic therapy for inflammatory bowel disease refractory to steroids |
title_fullStr |
Pharmacologic therapy for inflammatory bowel disease refractory to steroids |
title_full_unstemmed |
Pharmacologic therapy for inflammatory bowel disease refractory to steroids |
title_sort |
pharmacologic therapy for inflammatory bowel disease refractory to steroids |
publisher |
Dove Medical Press |
series |
Clinical and Experimental Gastroenterology |
issn |
1178-7023 |
publishDate |
2015-08-01 |
description |
MP Martínez-Montiel, B Casis-Herce , GJ Gómez-Gómez, A Masedo-González, C Yela-San Bernardino, C Piedracoba, G Castellano-Tortajada Division of Gastroenterology, Hospital 12 de Octubre, Madrid, SpainAbstract: Although corticosteroids are an effective treatment for induction of remission in inflammatory bowel disease (IBD), many patients are dependent on or refractory to corticosteroids. This review is based on scrutinizing current literature with emphasis on randomized controlled trials, meta-analyses, and Cochrane reviews on the management of IBD refractory to corticosteroids. Based on this evidence, we propose algorithms and optimization strategies for use of immunomodulator and biologic therapy in IBD refractory to corticosteroids.Keywords: immunomodulators, anti-tumor necrosis factor alpha, Crohn's disease, ulcerative colitis, drug levels, treatment optimization |
url |
http://www.dovepress.com/pharmacologic-therapy-for-inflammatory-bowel-disease-refractory-to-ste-peer-reviewed-article-CEG |
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1716790015904710656 |