The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

Induction of DNA damage by UVB and UVA radiation may generate mutations and genomic instability leading to carcinogenesis. Therefore, skin cells being repeatedly exposed to ultraviolet (UV) light have acquired multilayered protective mechanisms to avoid malignant transformation. Besides extensive DN...

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Bibliographic Details
Main Authors: Elwira Strozyk, Dagmar Kulms
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:International Journal of Molecular Sciences
Subjects:
UV
DNA damage
p53
AKT
mTOR
cell death
apoptosis
autophagy
senescence
heat shock
Online Access:http://www.mdpi.com/1422-0067/14/8/15260

Internet

http://www.mdpi.com/1422-0067/14/8/15260

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