Rifabutin corneal deposits localized to the deep stroma using anterior segment optical coherence tomography

• Main Authors: Tianyi Zhang, Catherine Q. Sun, Yijie B. Lin, Julie M. Schallhorn
• Format: Article
• Language: English
• Published: Elsevier 2020-06-01
• Series: American Journal of Ophthalmology Case Reports
• Subjects: Rifabutin; Corneal deposits; Mycobacterium avium complex; Confocal microscopy; Anterior segment OCT
• Online Access: http://www.sciencedirect.com/science/article/pii/S2451993618305000

Purpose: To demonstrate that rifabutin-related corneal deposits are localized to the deep stroma using anterior segment optical coherence tomography (OCT) and confocal microscopy. Observations: A 55-year-old male with a history of human immunodeficiency virus (HIV) and disseminated mycobacterium avium complex on rifabutin treatment for 3 years presented with bilateral corneal deposits. Confocal microscopy and anterior segment OCT confirm that rifabutin-related corneal deposits are located in the deep stroma, rather than in the endothelium. Conclusions: And Importance: Rifabutin deposits localize to the deep corneal stroma, and can be seen with both confocal microscopy and anterior segment OCT. Anterior segment OCT is a widely available and easily used diagnostic tool, and can provide utility in the diagnosis of corneal deposits.