3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

Currently technologies for monitoring and controlling neural activities in 3D models are lacking. Here the authors report a 3D high-density multielectrode array, with optical stimulation and drug delivery, to investigate neural circuit dynamics in engineered 3D neural tissues.

Bibliographic Details
Main Authors: Hyogeun Shin, Sohyeon Jeong, Ju-Hyun Lee, Woong Sun, Nakwon Choi, Il-Joo Cho
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20763-3
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spelling doaj-b7878afc0e8744b9ab07f36f003393402021-01-24T12:11:36ZengNature Publishing GroupNature Communications2041-17232021-01-0112111810.1038/s41467-020-20763-33D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamicsHyogeun Shin0Sohyeon Jeong1Ju-Hyun Lee2Woong Sun3Nakwon Choi4Il-Joo Cho5Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)Department of Anatomy, Korea University College of MedicineDepartment of Anatomy, Korea University College of MedicineCenter for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)Currently technologies for monitoring and controlling neural activities in 3D models are lacking. Here the authors report a 3D high-density multielectrode array, with optical stimulation and drug delivery, to investigate neural circuit dynamics in engineered 3D neural tissues.https://doi.org/10.1038/s41467-020-20763-3
collection DOAJ
language English
format Article
sources DOAJ
author Hyogeun Shin
Sohyeon Jeong
Ju-Hyun Lee
Woong Sun
Nakwon Choi
Il-Joo Cho
spellingShingle Hyogeun Shin
Sohyeon Jeong
Ju-Hyun Lee
Woong Sun
Nakwon Choi
Il-Joo Cho
3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
Nature Communications
author_facet Hyogeun Shin
Sohyeon Jeong
Ju-Hyun Lee
Woong Sun
Nakwon Choi
Il-Joo Cho
author_sort Hyogeun Shin
title 3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
title_short 3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
title_full 3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
title_fullStr 3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
title_full_unstemmed 3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
title_sort 3d high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description Currently technologies for monitoring and controlling neural activities in 3D models are lacking. Here the authors report a 3D high-density multielectrode array, with optical stimulation and drug delivery, to investigate neural circuit dynamics in engineered 3D neural tissues.
url https://doi.org/10.1038/s41467-020-20763-3
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AT sohyeonjeong 3dhighdensitymicroelectrodearraywithopticalstimulationanddrugdeliveryforinvestigatingneuralcircuitdynamics
AT juhyunlee 3dhighdensitymicroelectrodearraywithopticalstimulationanddrugdeliveryforinvestigatingneuralcircuitdynamics
AT woongsun 3dhighdensitymicroelectrodearraywithopticalstimulationanddrugdeliveryforinvestigatingneuralcircuitdynamics
AT nakwonchoi 3dhighdensitymicroelectrodearraywithopticalstimulationanddrugdeliveryforinvestigatingneuralcircuitdynamics
AT iljoocho 3dhighdensitymicroelectrodearraywithopticalstimulationanddrugdeliveryforinvestigatingneuralcircuitdynamics
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