Spatial Control of DNA Reaction Networks by DNA Sequence
We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the...
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MDPI AG
2012-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/11/13390 |
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doaj-b7878b8fd27f495caf45068df65357e82020-11-25T01:05:10ZengMDPI AGMolecules1420-30492012-11-011711133901340210.3390/molecules171113390Spatial Control of DNA Reaction Networks by DNA SequenceAndrew D. EllingtonXi ChenPeter B. AllenWe have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns.http://www.mdpi.com/1420-3049/17/11/13390reaction-diffusionelectrophoresischemical reaction networksDNA circuitsstrand displacement reactions |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Andrew D. Ellington Xi Chen Peter B. Allen |
| spellingShingle |
Andrew D. Ellington Xi Chen Peter B. Allen Spatial Control of DNA Reaction Networks by DNA Sequence Molecules reaction-diffusion electrophoresis chemical reaction networks DNA circuits strand displacement reactions |
| author_facet |
Andrew D. Ellington Xi Chen Peter B. Allen |
| author_sort |
Andrew D. Ellington |
| title |
Spatial Control of DNA Reaction Networks by DNA Sequence |
| title_short |
Spatial Control of DNA Reaction Networks by DNA Sequence |
| title_full |
Spatial Control of DNA Reaction Networks by DNA Sequence |
| title_fullStr |
Spatial Control of DNA Reaction Networks by DNA Sequence |
| title_full_unstemmed |
Spatial Control of DNA Reaction Networks by DNA Sequence |
| title_sort |
spatial control of dna reaction networks by dna sequence |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2012-11-01 |
| description |
We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns. |
| topic |
reaction-diffusion electrophoresis chemical reaction networks DNA circuits strand displacement reactions |
| url |
http://www.mdpi.com/1420-3049/17/11/13390 |
| work_keys_str_mv |
AT andrewdellington spatialcontrolofdnareactionnetworksbydnasequence AT xichen spatialcontrolofdnareactionnetworksbydnasequence AT peterballen spatialcontrolofdnareactionnetworksbydnasequence |
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1725195902255104000 |