Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we ra...
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2021-08-01
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doaj-b79ae75876f14fea94621325471eb6162021-08-29T11:47:26ZengNature Publishing Groupnpj Genomic Medicine2056-79442021-08-01611810.1038/s41525-021-00236-2Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patientsKurt D. Christensen0Erica F. Schonman1Jill O. Robinson2J. Scott Roberts3Pamela M. Diamond4Kaitlyn B. Lee5Robert C. Green6Amy L. McGuire7PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care InstituteDivision of Genetics, Department of Medicine, Brigham and Women’s HospitalCenter for Medical Ethics and Health Policy at Baylor College of MedicineDepartment of Health Behavior and Health Education, University of Michigan School of Public HealthCenter for Health Promotion and Prevention Research, University of Texas Houston School of Public HealthCenter for Medical Ethics and Health Policy at Baylor College of MedicineBroad Institute of Harvard and MITCenter for Medical Ethics and Health Policy at Baylor College of MedicineAbstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we randomized 100 apparently healthy, primary-care participants and 100 cardiology participants to receive a review of their family histories of disease, either alone or in addition to GS analyses. GS results included polygenic risk information for eight cardiometabolic conditions. Overall, no differences were observed between the percentage of participants in the GS and control arms, who reported changes to health behaviors such as diet and exercise at 6 months post disclosure (48% vs. 36%, respectively, p = 0.104). In the GS arm, however, the odds of reporting a behavior change increased by 52% per high-risk polygenic prediction (p = 0.032). Mean anxiety and depression scores for GS and control arms had confidence intervals within equivalence margins of ±1.5. Mediation analyses suggested an indirect impact of GS on health behaviors by causing positive psychological responses (p ≤ 0.001). Findings suggest that GS did not distress participants. Future research on GS in more diverse populations is needed to confirm that it does not raise risks for psychological harms and to confirm the ability of polygenic risk predictions to motivate preventive behaviors.https://doi.org/10.1038/s41525-021-00236-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kurt D. Christensen Erica F. Schonman Jill O. Robinson J. Scott Roberts Pamela M. Diamond Kaitlyn B. Lee Robert C. Green Amy L. McGuire |
spellingShingle |
Kurt D. Christensen Erica F. Schonman Jill O. Robinson J. Scott Roberts Pamela M. Diamond Kaitlyn B. Lee Robert C. Green Amy L. McGuire Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients npj Genomic Medicine |
author_facet |
Kurt D. Christensen Erica F. Schonman Jill O. Robinson J. Scott Roberts Pamela M. Diamond Kaitlyn B. Lee Robert C. Green Amy L. McGuire |
author_sort |
Kurt D. Christensen |
title |
Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients |
title_short |
Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients |
title_full |
Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients |
title_fullStr |
Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients |
title_full_unstemmed |
Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients |
title_sort |
behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients |
publisher |
Nature Publishing Group |
series |
npj Genomic Medicine |
issn |
2056-7944 |
publishDate |
2021-08-01 |
description |
Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we randomized 100 apparently healthy, primary-care participants and 100 cardiology participants to receive a review of their family histories of disease, either alone or in addition to GS analyses. GS results included polygenic risk information for eight cardiometabolic conditions. Overall, no differences were observed between the percentage of participants in the GS and control arms, who reported changes to health behaviors such as diet and exercise at 6 months post disclosure (48% vs. 36%, respectively, p = 0.104). In the GS arm, however, the odds of reporting a behavior change increased by 52% per high-risk polygenic prediction (p = 0.032). Mean anxiety and depression scores for GS and control arms had confidence intervals within equivalence margins of ±1.5. Mediation analyses suggested an indirect impact of GS on health behaviors by causing positive psychological responses (p ≤ 0.001). Findings suggest that GS did not distress participants. Future research on GS in more diverse populations is needed to confirm that it does not raise risks for psychological harms and to confirm the ability of polygenic risk predictions to motivate preventive behaviors. |
url |
https://doi.org/10.1038/s41525-021-00236-2 |
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