STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose

STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose

Abstract Background Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might mediate the process of renal fibrosis, which could induce the expression of...

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Bibliographic Details
Main Authors: Xiaoxiao Yang, Manchen Bao, Yi Fang, Xiaofang Yu, Jun Ji, Xiaoqiang Ding
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Translational Medicine
Subjects:
Peritoneal dialysis
Peritoneal fibrosis
STAT3
HIF-1α
Epithelial-mesenchymal transition
Online Access:https://doi.org/10.1186/s12967-021-02946-8

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