Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor

Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor

Macrophages are heterogeneous immune cells with distinct origins, phenotypes, functions, and tissue localization. Their susceptibility to HIV-1 is subject to variations from permissiveness to resistance, owing in part to regulatory microRNAs. Here, we used RNA sequencing (RNA-seq) to examine the exp...

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Bibliographic Details
Main Authors: Robert Lodge, Jérémy A. Ferreira Barbosa, Félix Lombard-Vadnais, Julian C. Gilmore, Alexandre Deshiere, Annie Gosselin, Tomas Raul Wiche Salinas, Mariana G. Bego, Christopher Power, Jean-Pierre Routy, Petronela Ancuta, Michel J. Tremblay, Éric A. Cohen
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
HIV-1
macrophage
microRNA
TNF-α
macrophage activation
CD4
miR-221
miR-222
antiviral
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313050

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