Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients
Background It is unclear whether the chemotherapy response improves after exposure to immunotherapy. Antiangiogenic agents have been shown to stimulate the immune system and cause synergistic effects that stimulate tumor shrinkage. We conducted a retrospective study to evaluate improvement of the ef...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2019-04-01
|
Series: | Thoracic Cancer |
Subjects: | |
Online Access: | https://doi.org/10.1111/1759-7714.12998 |
id |
doaj-b7a3f30fd0304a4297a6015c537f6965 |
---|---|
record_format |
Article |
spelling |
doaj-b7a3f30fd0304a4297a6015c537f69652020-11-24T21:28:57ZengWileyThoracic Cancer1759-77061759-77142019-04-0110477578110.1111/1759-7714.12998Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patientsAyako Shiono0Kyoichi Kaira1Atsuto Mouri2Ou Yamaguchi3Kosuke Hashimoto4Takahiro Uchida5Yu Miura6Fuyumi Nishihara7Yoshitake Murayama8Kunihiko Kobayashi9Hiroshi Kagamu10Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center Saitama Medical University Hidaka‐City JapanBackground It is unclear whether the chemotherapy response improves after exposure to immunotherapy. Antiangiogenic agents have been shown to stimulate the immune system and cause synergistic effects that stimulate tumor shrinkage. We conducted a retrospective study to evaluate improvement of the efficacy of ramucirumab plus docetaxel after the failure of nivolumab as a PD‐1 inhibitor. Methods From February 2016 to December 2017, 152 patients with non‐small cell lung cancer (NSCLC) administered nivolumab in our institution were identified. We reviewed the records of 20 NSCLC patients administered ramucirumab plus docetaxel after nivolumab failure. The overall response rate (ORR), progression‐free survival (PFS), and overall survival (OS) were investigated. Pegylated granulocyte colony‐stimulating factor was prophylactically administered to 18 patients (90%) after the administration of ramucirumab plus docetaxel. Results The median age of the patients was 70 (range: 55–77) years. Twelve patients were male and eight were female. The histology was adenocarcinoma in 16 patients, squamous cell carcinoma in three, and other in one. The ORR of ramucirumab plus docetaxel was 60%, and the PFS and OS were 169 and 343 days, respectively. Among the 20 patients, 12 achieved a partial response, giving an ORR of 60.0%. Six patients had stable disease and two had progressive disease. The disease control rate was 90%. Gastrointestinal adverse events were frequently observed in 19 patients. Conclusions Ramucirumab plus docetaxel achieved a higher response rate when administered immediately after nivolumab failure compared to regimens without prior nivolumab administration.https://doi.org/10.1111/1759-7714.12998Chemotherapydocetaxelincreased responsenivolumabramucirumab |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ayako Shiono Kyoichi Kaira Atsuto Mouri Ou Yamaguchi Kosuke Hashimoto Takahiro Uchida Yu Miura Fuyumi Nishihara Yoshitake Murayama Kunihiko Kobayashi Hiroshi Kagamu |
spellingShingle |
Ayako Shiono Kyoichi Kaira Atsuto Mouri Ou Yamaguchi Kosuke Hashimoto Takahiro Uchida Yu Miura Fuyumi Nishihara Yoshitake Murayama Kunihiko Kobayashi Hiroshi Kagamu Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients Thoracic Cancer Chemotherapy docetaxel increased response nivolumab ramucirumab |
author_facet |
Ayako Shiono Kyoichi Kaira Atsuto Mouri Ou Yamaguchi Kosuke Hashimoto Takahiro Uchida Yu Miura Fuyumi Nishihara Yoshitake Murayama Kunihiko Kobayashi Hiroshi Kagamu |
author_sort |
Ayako Shiono |
title |
Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients |
title_short |
Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients |
title_full |
Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients |
title_fullStr |
Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients |
title_full_unstemmed |
Improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients |
title_sort |
improved efficacy of ramucirumab plus docetaxel after nivolumab failure in previously treated non‐small cell lung cancer patients |
publisher |
Wiley |
series |
Thoracic Cancer |
issn |
1759-7706 1759-7714 |
publishDate |
2019-04-01 |
description |
Background It is unclear whether the chemotherapy response improves after exposure to immunotherapy. Antiangiogenic agents have been shown to stimulate the immune system and cause synergistic effects that stimulate tumor shrinkage. We conducted a retrospective study to evaluate improvement of the efficacy of ramucirumab plus docetaxel after the failure of nivolumab as a PD‐1 inhibitor. Methods From February 2016 to December 2017, 152 patients with non‐small cell lung cancer (NSCLC) administered nivolumab in our institution were identified. We reviewed the records of 20 NSCLC patients administered ramucirumab plus docetaxel after nivolumab failure. The overall response rate (ORR), progression‐free survival (PFS), and overall survival (OS) were investigated. Pegylated granulocyte colony‐stimulating factor was prophylactically administered to 18 patients (90%) after the administration of ramucirumab plus docetaxel. Results The median age of the patients was 70 (range: 55–77) years. Twelve patients were male and eight were female. The histology was adenocarcinoma in 16 patients, squamous cell carcinoma in three, and other in one. The ORR of ramucirumab plus docetaxel was 60%, and the PFS and OS were 169 and 343 days, respectively. Among the 20 patients, 12 achieved a partial response, giving an ORR of 60.0%. Six patients had stable disease and two had progressive disease. The disease control rate was 90%. Gastrointestinal adverse events were frequently observed in 19 patients. Conclusions Ramucirumab plus docetaxel achieved a higher response rate when administered immediately after nivolumab failure compared to regimens without prior nivolumab administration. |
topic |
Chemotherapy docetaxel increased response nivolumab ramucirumab |
url |
https://doi.org/10.1111/1759-7714.12998 |
work_keys_str_mv |
AT ayakoshiono improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT kyoichikaira improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT atsutomouri improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT ouyamaguchi improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT kosukehashimoto improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT takahirouchida improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT yumiura improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT fuyuminishihara improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT yoshitakemurayama improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT kunihikokobayashi improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients AT hiroshikagamu improvedefficacyoframucirumabplusdocetaxelafternivolumabfailureinpreviouslytreatednonsmallcelllungcancerpatients |
_version_ |
1725968311044276224 |