Circadian Rhythm Gene PER3 Negatively Regulates Stemness of Prostate Cancer Stem Cells via WNT/β-Catenin Signaling in Tumor Microenvironment

Circadian Rhythm Gene PER3 Negatively Regulates Stemness of Prostate Cancer Stem Cells via WNT/β-Catenin Signaling in Tumor Microenvironment

Prostate cancer (PCa) cells are heterogeneous, containing a variety of cancer cells with phenotypical and functional discrepancies in the tumor microenvironment, where prostate cancer stem cells (PCSCs) play a vital role in PCa development. Our earlier studies have shown that ALDHhiCD44+ (DP) PCa ce...

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Bibliographic Details
Main Authors: Qilin Li, Ding Xia, Zhihua Wang, Bo Liu, Jing Zhang, Ping Peng, Qiujun Tang, Jie Dong, Juan Guo, Dong Kuang, Weimin Chen, Jing Mao, Qiuhui Li, Xin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
prostate cancer stem cells
prostate cancer
tumor microenvironment
PER3
Wnt/β-catenin signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.656981/full

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