Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus
Background: To investigate the association between serum bilirubin (BIL) levels and the progression of albuminuria in type 2 diabetic Taiwanese. Methods: Longitudinal data from January 2001 to June 2015 were retrospectively reviewed from Chang Gung Memorial Hospital in Taiwan. A total of 2877 type 2...
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doaj-b7ab1fb9496e4d61bb051a29240ca06d2021-05-30T04:43:43ZengElsevierBiomedical Journal2319-41702021-04-01442201208Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitusWai Kin Chan0Sung-Sheng Tsai1Yan-Rong Li2Wei-Yu Chou3Hsiao-Lien Chen4Szu-Tah Chen5Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, 5, Fusing St., Gueishan, Taoyuan, 333, Taiwan.Background: To investigate the association between serum bilirubin (BIL) levels and the progression of albuminuria in type 2 diabetic Taiwanese. Methods: Longitudinal data from January 2001 to June 2015 were retrospectively reviewed from Chang Gung Memorial Hospital in Taiwan. A total of 2877 type 2 diabetic patients with normal total BIL levels were divided into 4 groups according to BIL, with the highest BIL in the fourth group. The urinary albumin/creatinine ratio (UACR) trend and progression, as well as other laboratory measurements, were evaluated among the four groups. The cumulative incidence and Cox proportional hazard model analysis were performed to examine the relationship between BIL and the risk of albuminuria progression (AUPr). Results: The mean duration of follow-up was 1.5 years (±1.37 years). The mean patient age, glycosylated hemoglobin level, and duration of diabetes were 62.52 years, 7.9%, and 3.94 years, respectively. A significant correlation was observed between BIL and both the UACR at baseline (P < 0.001) and the cumulative incidence of AUPr (log–rank test, P = 0.031). Hazard ratio (HR) analysis revealed that patients in the fourth BIL quartile had the lowest HR risk of AUPr among the four groups (adjusted HR = 0.70; 95% Confidence Interval = 0.56–0.89, P < 0.05). Conclusions: Higher serum BIL levels are associated with a lower risk of AUPr in type 2 diabetes patients in Taiwan.http://www.sciencedirect.com/science/article/pii/S2319417019305268AlbuminuriaBilirubinChronic kidney diseasesDiabetic nephropathy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wai Kin Chan Sung-Sheng Tsai Yan-Rong Li Wei-Yu Chou Hsiao-Lien Chen Szu-Tah Chen |
spellingShingle |
Wai Kin Chan Sung-Sheng Tsai Yan-Rong Li Wei-Yu Chou Hsiao-Lien Chen Szu-Tah Chen Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus Biomedical Journal Albuminuria Bilirubin Chronic kidney diseases Diabetic nephropathy |
author_facet |
Wai Kin Chan Sung-Sheng Tsai Yan-Rong Li Wei-Yu Chou Hsiao-Lien Chen Szu-Tah Chen |
author_sort |
Wai Kin Chan |
title |
Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus |
title_short |
Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus |
title_full |
Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus |
title_fullStr |
Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus |
title_full_unstemmed |
Association between serum bilirubin levels and progression of albuminuria in Taiwanese with type 2 diabetes mellitus |
title_sort |
association between serum bilirubin levels and progression of albuminuria in taiwanese with type 2 diabetes mellitus |
publisher |
Elsevier |
series |
Biomedical Journal |
issn |
2319-4170 |
publishDate |
2021-04-01 |
description |
Background: To investigate the association between serum bilirubin (BIL) levels and the progression of albuminuria in type 2 diabetic Taiwanese. Methods: Longitudinal data from January 2001 to June 2015 were retrospectively reviewed from Chang Gung Memorial Hospital in Taiwan. A total of 2877 type 2 diabetic patients with normal total BIL levels were divided into 4 groups according to BIL, with the highest BIL in the fourth group. The urinary albumin/creatinine ratio (UACR) trend and progression, as well as other laboratory measurements, were evaluated among the four groups. The cumulative incidence and Cox proportional hazard model analysis were performed to examine the relationship between BIL and the risk of albuminuria progression (AUPr). Results: The mean duration of follow-up was 1.5 years (±1.37 years). The mean patient age, glycosylated hemoglobin level, and duration of diabetes were 62.52 years, 7.9%, and 3.94 years, respectively. A significant correlation was observed between BIL and both the UACR at baseline (P < 0.001) and the cumulative incidence of AUPr (log–rank test, P = 0.031). Hazard ratio (HR) analysis revealed that patients in the fourth BIL quartile had the lowest HR risk of AUPr among the four groups (adjusted HR = 0.70; 95% Confidence Interval = 0.56–0.89, P < 0.05). Conclusions: Higher serum BIL levels are associated with a lower risk of AUPr in type 2 diabetes patients in Taiwan. |
topic |
Albuminuria Bilirubin Chronic kidney diseases Diabetic nephropathy |
url |
http://www.sciencedirect.com/science/article/pii/S2319417019305268 |
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