A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?
Main Authors: | Krystel El Hage, Jean-Philip Piquemal, Nassima Oumata, Laurent Meijer, Hervé Galons, Nohad Gresh |
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Format: | Article |
Language: | English |
Published: |
American Chemical Society
2017-07-01
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Series: | ACS Omega |
Online Access: | http://dx.doi.org/10.1021/acsomega.7b00471 |
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