Recent development of nanomedicine for the treatment of bacterial biofilm infections
Abstract Bacterial biofilm related infections are ever growing issues for global medical community. Traditional antibiotic therapy is usually ineffective for treating them because the bacteria inside biofilms have evolved with multiple mechanisms to evade antibiotic challenge. Hence, effective thera...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2021-02-01
|
Series: | View |
Subjects: | |
Online Access: | https://doi.org/10.1002/VIW.20200065 |
id |
doaj-b7b7f4e45276400cbcacf7af0ea7954c |
---|---|
record_format |
Article |
spelling |
doaj-b7b7f4e45276400cbcacf7af0ea7954c2021-02-06T15:40:36ZengWileyView2688-39882688-268X2021-02-0121n/an/a10.1002/VIW.20200065Recent development of nanomedicine for the treatment of bacterial biofilm infectionsWeijun Xiu0Jingyang Shan1Kaili Yang2Hang Xiao3Lihui Yuwen4Lianhui Wang5Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing ChinaKey Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing ChinaKey Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing ChinaKey Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing ChinaKey Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing ChinaKey Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts and Telecommunications Nanjing ChinaAbstract Bacterial biofilm related infections are ever growing issues for global medical community. Traditional antibiotic therapy is usually ineffective for treating them because the bacteria inside biofilms have evolved with multiple mechanisms to evade antibiotic challenge. Hence, effective therapeutic strategy with novel antibiofilm mode of action is highly desired. In this context, nanomedicine has drawn great attentions and has been proven promising to prevent and eliminate bacterial biofilms. In this review, we focus on the recent advance of nanotechnology‐based strategies and nanoagents for combating bacterial biofilm infections. First, typical antibiofilm nanotechnologies utilized different chemical, physical, and biological properties of nanomaterials are discussed. Second, smart nanoagents that can responsive to biofilm microenvironment, including pH, H2O2, and enzymes, are shown. Third, some promising antibiofilm approaches, such as theranostics, biofilm structure destruction, and quorum sensing inhibition, are also demonstrated. Finally, we conclude the current antibiofilm nanotechnologies and discuss the challenges and future directions in this field.https://doi.org/10.1002/VIW.20200065antibiofilmbacterial biofilmsEPSnanomedicineresponsive |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Weijun Xiu Jingyang Shan Kaili Yang Hang Xiao Lihui Yuwen Lianhui Wang |
spellingShingle |
Weijun Xiu Jingyang Shan Kaili Yang Hang Xiao Lihui Yuwen Lianhui Wang Recent development of nanomedicine for the treatment of bacterial biofilm infections View antibiofilm bacterial biofilms EPS nanomedicine responsive |
author_facet |
Weijun Xiu Jingyang Shan Kaili Yang Hang Xiao Lihui Yuwen Lianhui Wang |
author_sort |
Weijun Xiu |
title |
Recent development of nanomedicine for the treatment of bacterial biofilm infections |
title_short |
Recent development of nanomedicine for the treatment of bacterial biofilm infections |
title_full |
Recent development of nanomedicine for the treatment of bacterial biofilm infections |
title_fullStr |
Recent development of nanomedicine for the treatment of bacterial biofilm infections |
title_full_unstemmed |
Recent development of nanomedicine for the treatment of bacterial biofilm infections |
title_sort |
recent development of nanomedicine for the treatment of bacterial biofilm infections |
publisher |
Wiley |
series |
View |
issn |
2688-3988 2688-268X |
publishDate |
2021-02-01 |
description |
Abstract Bacterial biofilm related infections are ever growing issues for global medical community. Traditional antibiotic therapy is usually ineffective for treating them because the bacteria inside biofilms have evolved with multiple mechanisms to evade antibiotic challenge. Hence, effective therapeutic strategy with novel antibiofilm mode of action is highly desired. In this context, nanomedicine has drawn great attentions and has been proven promising to prevent and eliminate bacterial biofilms. In this review, we focus on the recent advance of nanotechnology‐based strategies and nanoagents for combating bacterial biofilm infections. First, typical antibiofilm nanotechnologies utilized different chemical, physical, and biological properties of nanomaterials are discussed. Second, smart nanoagents that can responsive to biofilm microenvironment, including pH, H2O2, and enzymes, are shown. Third, some promising antibiofilm approaches, such as theranostics, biofilm structure destruction, and quorum sensing inhibition, are also demonstrated. Finally, we conclude the current antibiofilm nanotechnologies and discuss the challenges and future directions in this field. |
topic |
antibiofilm bacterial biofilms EPS nanomedicine responsive |
url |
https://doi.org/10.1002/VIW.20200065 |
work_keys_str_mv |
AT weijunxiu recentdevelopmentofnanomedicineforthetreatmentofbacterialbiofilminfections AT jingyangshan recentdevelopmentofnanomedicineforthetreatmentofbacterialbiofilminfections AT kailiyang recentdevelopmentofnanomedicineforthetreatmentofbacterialbiofilminfections AT hangxiao recentdevelopmentofnanomedicineforthetreatmentofbacterialbiofilminfections AT lihuiyuwen recentdevelopmentofnanomedicineforthetreatmentofbacterialbiofilminfections AT lianhuiwang recentdevelopmentofnanomedicineforthetreatmentofbacterialbiofilminfections |
_version_ |
1724282175798378496 |