Effect of Nigella sativa on reproductive system in experimental menopause rat model
Objective: Menopause is the condition when regular menstrual periods cease and may be accompanied by psychological and physical symptoms. The purpose of current study was to determine Nigella sativa effects on reproductive system in experimental menopause animal models. Materials and Methods: A seri...
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Mashhad University of Medical Sciences
2016-01-01
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doaj-b7be40e0342d4e548e693a59ccecccf42020-11-24T22:43:22ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492016-01-0161951036079Effect of Nigella sativa on reproductive system in experimental menopause rat modelSaadat Parhizkar0Latiffah Latiff1Ali Parsa2Medicinal Plants Research Centre, Yasuj University of Medical Sciences, Yasuj, IranDepartment of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia (UPM)Department of Chemistry, College of Science, Shahre Rey Branch, Islamic Azad University, Tehran, IranObjective: Menopause is the condition when regular menstrual periods cease and may be accompanied by psychological and physical symptoms. The purpose of current study was to determine Nigella sativa effects on reproductive system in experimental menopause animal models. Materials and Methods: A series of experiments wasconducted to investigate the effects of different dosages of N. sativa (first experiment), various extracts of N. sativa (second experiment)and some of its ingredients (third experiment) on selected menopausal parameters of ovariectomized (OVX) rats. Forty different OVX rats were equally divided into 5 groups and administered with one of the following treatments for 21 days: conjugated equine estrogen (positive control), distilled water or olive oil (negative control), treatment groups (N. sativa300, 600 and 1200 mg/kg in the first experiment), (300mg/kg methanol, hexane and SFE extracts of N. sativa in the second experiment) and (linoleic acid 50 mg/kg, gamma linolenic acid 10mg/kg, and thymoquinone 15mg/kg in the third experiment). Results: The results demonstrated that N.sativa exert estrogenic effect were exhibited through uterotrophic assay and vaginal cell cornification as well as blood estrogen level. Furthermore, low dose N. sativa, methanol extract and linoleic acid had prominent estrogenic like effects which were significantly different from those of control group (phttp://ajp.mums.ac.ir/pdf_6079_ec23387ad355c8703ce9358676f94559.htmlMenopauseNigella sativaOvariectomized rats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saadat Parhizkar Latiffah Latiff Ali Parsa |
spellingShingle |
Saadat Parhizkar Latiffah Latiff Ali Parsa Effect of Nigella sativa on reproductive system in experimental menopause rat model Avicenna Journal of Phytomedicine Menopause Nigella sativa Ovariectomized rats |
author_facet |
Saadat Parhizkar Latiffah Latiff Ali Parsa |
author_sort |
Saadat Parhizkar |
title |
Effect of Nigella sativa on reproductive system in experimental menopause rat model |
title_short |
Effect of Nigella sativa on reproductive system in experimental menopause rat model |
title_full |
Effect of Nigella sativa on reproductive system in experimental menopause rat model |
title_fullStr |
Effect of Nigella sativa on reproductive system in experimental menopause rat model |
title_full_unstemmed |
Effect of Nigella sativa on reproductive system in experimental menopause rat model |
title_sort |
effect of nigella sativa on reproductive system in experimental menopause rat model |
publisher |
Mashhad University of Medical Sciences |
series |
Avicenna Journal of Phytomedicine |
issn |
2228-7930 2228-7949 |
publishDate |
2016-01-01 |
description |
Objective: Menopause is the condition when regular menstrual periods cease and may be accompanied by psychological and physical symptoms. The purpose of current study was to determine Nigella sativa effects on reproductive system in experimental menopause animal models. Materials and Methods: A series of experiments wasconducted to investigate the effects of different dosages of N. sativa (first experiment), various extracts of N. sativa (second experiment)and some of its ingredients (third experiment) on selected menopausal parameters of ovariectomized (OVX) rats. Forty different OVX rats were equally divided into 5 groups and administered with one of the following treatments for 21 days: conjugated equine estrogen (positive control), distilled water or olive oil (negative control), treatment groups (N. sativa300, 600 and 1200 mg/kg in the first experiment), (300mg/kg methanol, hexane and SFE extracts of N. sativa in the second experiment) and (linoleic acid 50 mg/kg, gamma linolenic acid 10mg/kg, and thymoquinone 15mg/kg in the third experiment). Results: The results demonstrated that N.sativa exert estrogenic effect were exhibited through uterotrophic assay and vaginal cell cornification as well as blood estrogen level. Furthermore, low dose N. sativa, methanol extract and linoleic acid had prominent estrogenic like effects which were significantly different from those of control group (p |
topic |
Menopause Nigella sativa Ovariectomized rats |
url |
http://ajp.mums.ac.ir/pdf_6079_ec23387ad355c8703ce9358676f94559.html |
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