In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication
Abstract Neuroimmune communication contributes to both baseline and adaptive physiological functions, as well as disease states. The vascular blood–brain barrier (BBB) and associated cells of the neurovascular unit (NVU) serve as an important interface for immune communication between the brain and...
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doaj-b7bf0a87435e4977be06fd7ab8c1035a2020-11-25T02:29:03ZengBMCFluids and Barriers of the CNS2045-81182020-03-0117111610.1186/s12987-020-00187-3In vitro modeling of blood–brain barrier and interface functions in neuroimmune communicationMichelle A. Erickson0Miranda L. Wilson1William A. Banks2Geriatric Research Education and Clinical Center, VA Puget Sound Healthcare SystemGeriatric Research Education and Clinical Center, VA Puget Sound Healthcare SystemGeriatric Research Education and Clinical Center, VA Puget Sound Healthcare SystemAbstract Neuroimmune communication contributes to both baseline and adaptive physiological functions, as well as disease states. The vascular blood–brain barrier (BBB) and associated cells of the neurovascular unit (NVU) serve as an important interface for immune communication between the brain and periphery through the blood. Immune functions and interactions of the BBB and NVU in this context can be categorized into at least five neuroimmune axes, which include (1) immune modulation of BBB impermeability, (2) immune regulation of BBB transporters, secretions, and other functions, (3) BBB uptake and transport of immunoactive substances, (4) immune cell trafficking, and (5) BBB secretions of immunoactive substances. These axes may act separately or in concert to mediate various aspects of immune signaling at the BBB. Much of what we understand about immune axes has been from work conducted using in vitro BBB models, and recent advances in BBB and NVU modeling highlight the potential of these newer models for improving our understanding of how the brain and immune system communicate. In this review, we discuss how conventional in vitro models of the BBB have improved our understanding of the 5 neuroimmune axes. We further evaluate the existing literature on neuroimmune functions of novel in vitro BBB models, such as those derived from human induced pluripotent stem cells (iPSCs) and discuss their utility in evaluating aspects of neuroimmune communication.http://link.springer.com/article/10.1186/s12987-020-00187-3Blood–brain barrierChemokinesCytokinesIn vitroLeukocyte traffickingNeuroimmune |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michelle A. Erickson Miranda L. Wilson William A. Banks |
spellingShingle |
Michelle A. Erickson Miranda L. Wilson William A. Banks In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication Fluids and Barriers of the CNS Blood–brain barrier Chemokines Cytokines In vitro Leukocyte trafficking Neuroimmune |
author_facet |
Michelle A. Erickson Miranda L. Wilson William A. Banks |
author_sort |
Michelle A. Erickson |
title |
In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication |
title_short |
In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication |
title_full |
In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication |
title_fullStr |
In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication |
title_full_unstemmed |
In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication |
title_sort |
in vitro modeling of blood–brain barrier and interface functions in neuroimmune communication |
publisher |
BMC |
series |
Fluids and Barriers of the CNS |
issn |
2045-8118 |
publishDate |
2020-03-01 |
description |
Abstract Neuroimmune communication contributes to both baseline and adaptive physiological functions, as well as disease states. The vascular blood–brain barrier (BBB) and associated cells of the neurovascular unit (NVU) serve as an important interface for immune communication between the brain and periphery through the blood. Immune functions and interactions of the BBB and NVU in this context can be categorized into at least five neuroimmune axes, which include (1) immune modulation of BBB impermeability, (2) immune regulation of BBB transporters, secretions, and other functions, (3) BBB uptake and transport of immunoactive substances, (4) immune cell trafficking, and (5) BBB secretions of immunoactive substances. These axes may act separately or in concert to mediate various aspects of immune signaling at the BBB. Much of what we understand about immune axes has been from work conducted using in vitro BBB models, and recent advances in BBB and NVU modeling highlight the potential of these newer models for improving our understanding of how the brain and immune system communicate. In this review, we discuss how conventional in vitro models of the BBB have improved our understanding of the 5 neuroimmune axes. We further evaluate the existing literature on neuroimmune functions of novel in vitro BBB models, such as those derived from human induced pluripotent stem cells (iPSCs) and discuss their utility in evaluating aspects of neuroimmune communication. |
topic |
Blood–brain barrier Chemokines Cytokines In vitro Leukocyte trafficking Neuroimmune |
url |
http://link.springer.com/article/10.1186/s12987-020-00187-3 |
work_keys_str_mv |
AT michelleaerickson invitromodelingofbloodbrainbarrierandinterfacefunctionsinneuroimmunecommunication AT mirandalwilson invitromodelingofbloodbrainbarrierandinterfacefunctionsinneuroimmunecommunication AT williamabanks invitromodelingofbloodbrainbarrierandinterfacefunctionsinneuroimmunecommunication |
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