<i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and Pharmacology
<i>Bergenia </i>(Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhi...
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doaj-b7d54fdbe8ed4fb6b6b34affc4c3f3a22020-11-27T08:11:22ZengMDPI AGMolecules1420-30492020-11-01255555555510.3390/molecules25235555<i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and PharmacologyBhupendra Koul0Arvind Kumar1Dhananjay Yadav2Jun-O. Jin3School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, IndiaResearch Center for Chromatography and Mass Spectrometry, CROM-MASS, CIBIMOL-CENIVAM, Industrial University of Santander, Carrera 27, Calle 9, Edificio 45, Bucaramanga 680002, ColombiaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, KoreaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea<i>Bergenia </i>(Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhizomes of <i>B. ligulata</i>. <i>Bergenia </i>species also possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic. This review provides explicit information on the traditional uses, phytochemistry, and pharmacological significance of the genus <i>Bergenia</i>. The extant literature concerned was systematically collected from various databases, weblinks, blogs, books, and theses to select 174 references for detailed analysis. To date, 152 chemical constituents have been identified and characterized from the genus <i>Bergenia</i> that belong to the chemical classes of polyphenols, phenolic-glycosides, lactones, quinones, sterols, tannins, terpenes, and others. <i>B. crassifolia</i> alone possesses 104 bioactive compounds. Meticulous pharmacological and phytochemical studies on <i>Bergenia</i> species and its conservation could yield more reliable compounds and products of pharmacological significance for better healthcare.https://www.mdpi.com/1420-3049/25/23/5555<i>Bergenia</i> speciesbotanical descriptiontraditional usesphytochemistrypharmacologyanti-urolithiatic activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bhupendra Koul Arvind Kumar Dhananjay Yadav Jun-O. Jin |
spellingShingle |
Bhupendra Koul Arvind Kumar Dhananjay Yadav Jun-O. Jin <i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and Pharmacology Molecules <i>Bergenia</i> species botanical description traditional uses phytochemistry pharmacology anti-urolithiatic activity |
author_facet |
Bhupendra Koul Arvind Kumar Dhananjay Yadav Jun-O. Jin |
author_sort |
Bhupendra Koul |
title |
<i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_short |
<i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_full |
<i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_fullStr |
<i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_full_unstemmed |
<i>Bergenia</i> Genus: Traditional Uses, Phytochemistry and Pharmacology |
title_sort |
<i>bergenia</i> genus: traditional uses, phytochemistry and pharmacology |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-11-01 |
description |
<i>Bergenia </i>(Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug formulation obtained from the rhizomes of <i>B. ligulata</i>. <i>Bergenia </i>species also possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic. This review provides explicit information on the traditional uses, phytochemistry, and pharmacological significance of the genus <i>Bergenia</i>. The extant literature concerned was systematically collected from various databases, weblinks, blogs, books, and theses to select 174 references for detailed analysis. To date, 152 chemical constituents have been identified and characterized from the genus <i>Bergenia</i> that belong to the chemical classes of polyphenols, phenolic-glycosides, lactones, quinones, sterols, tannins, terpenes, and others. <i>B. crassifolia</i> alone possesses 104 bioactive compounds. Meticulous pharmacological and phytochemical studies on <i>Bergenia</i> species and its conservation could yield more reliable compounds and products of pharmacological significance for better healthcare. |
topic |
<i>Bergenia</i> species botanical description traditional uses phytochemistry pharmacology anti-urolithiatic activity |
url |
https://www.mdpi.com/1420-3049/25/23/5555 |
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