CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.

The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression. The process of adaptation occurs when cells are presented with persistent or irreparable DNA damage and escape the cell-cycle arrest imposed...

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Bibliographic Details
Main Authors: Genevieve M Vidanes, Frédéric D Sweeney, Sarah Galicia, Stephanie Cheung, John P Doyle, Daniel Durocher, David P Toczyski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2811153?pdf=render

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http://europepmc.org/articles/PMC2811153?pdf=render

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