Monocyte progenitors give rise to multinucleated giant cells
Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
Bibliographic Details
| Main Authors: |
Anne Kathrin Lösslein,
Florens Lohrmann,
Lisa Scheuermann,
Kourosh Gharun,
Jana Neuber,
Julia Kolter,
Aaron James Forde,
Christian Kleimeyer,
Ying Yee Poh,
Matthias Mack,
Antigoni Triantafyllopoulou,
Micah D. Dunlap,
Shabaana A. Khader,
Maximilian Seidl,
Alexandra Hölscher,
Christoph Hölscher,
Xue Li Guan,
Anca Dorhoi,
Philipp Henneke |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22103-5
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