Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment
Glioma is the most common malignant tumor of the central nervous system, and it isdifficult to cure. The growth of malignant glioma is invasive. In recent decades, the strategy of surgicalresection combined with concurrent radiotherapy and chemotheraphy, and immunocheckpoint inhibitorshave been made...
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doaj-b7e4993d807b4ac88ba02f4f49a85a342020-11-24T21:00:47ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312020-02-0120273782040Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironmentYi⁃ming ZHANGSheng⁃ping YUPei⁃dong LIUTao LILiang ZHANGYang XIEJia⁃bo LIJin⁃hao ZHANGXiao⁃guang FANXue⁃jun YANGGlioma is the most common malignant tumor of the central nervous system, and it isdifficult to cure. The growth of malignant glioma is invasive. In recent decades, the strategy of surgicalresection combined with concurrent radiotherapy and chemotheraphy, and immunocheckpoint inhibitorshave been made progress. However, the therapeutic effect is still not ideal, which may be related to the lowimmunogenicity of tumor cells and the immunosuppression of tumor microenvironment (TME). In the TME,immune cells compete with glioma cells and other proliferating cells for nutrients, while metabolites in theTME affect the differentiation and functions of immune cells. This article summarizes the research progressof glioma metabolism regulation and tumor immunosuppressive microenvironment in recent years, whichprovides new ideas for the study of the mechanism of tumor progression and glioma of treatment. DOI:10.3969/j.issn.1672-6731.2020.02.002http://www.cjcnn.org/index.php/cjcnn/article/view/2085gliomatumor microenvironmentneoplastic stem cellsimmunity, cellularreview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi⁃ming ZHANG Sheng⁃ping YU Pei⁃dong LIU Tao LI Liang ZHANG Yang XIE Jia⁃bo LI Jin⁃hao ZHANG Xiao⁃guang FAN Xue⁃jun YANG |
spellingShingle |
Yi⁃ming ZHANG Sheng⁃ping YU Pei⁃dong LIU Tao LI Liang ZHANG Yang XIE Jia⁃bo LI Jin⁃hao ZHANG Xiao⁃guang FAN Xue⁃jun YANG Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment Chinese Journal of Contemporary Neurology and Neurosurgery glioma tumor microenvironment neoplastic stem cells immunity, cellular review |
author_facet |
Yi⁃ming ZHANG Sheng⁃ping YU Pei⁃dong LIU Tao LI Liang ZHANG Yang XIE Jia⁃bo LI Jin⁃hao ZHANG Xiao⁃guang FAN Xue⁃jun YANG |
author_sort |
Yi⁃ming ZHANG |
title |
Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment |
title_short |
Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment |
title_full |
Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment |
title_fullStr |
Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment |
title_full_unstemmed |
Regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment |
title_sort |
regulation of tumor immunity by metabolism of glioma cells and immune cells in tumor microenvironment |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2020-02-01 |
description |
Glioma is the most common malignant tumor of the central nervous system, and it isdifficult to cure. The growth of malignant glioma is invasive. In recent decades, the strategy of surgicalresection combined with concurrent radiotherapy and chemotheraphy, and immunocheckpoint inhibitorshave been made progress. However, the therapeutic effect is still not ideal, which may be related to the lowimmunogenicity of tumor cells and the immunosuppression of tumor microenvironment (TME). In the TME,immune cells compete with glioma cells and other proliferating cells for nutrients, while metabolites in theTME affect the differentiation and functions of immune cells. This article summarizes the research progressof glioma metabolism regulation and tumor immunosuppressive microenvironment in recent years, whichprovides new ideas for the study of the mechanism of tumor progression and glioma of treatment.
DOI:10.3969/j.issn.1672-6731.2020.02.002 |
topic |
glioma tumor microenvironment neoplastic stem cells immunity, cellular review |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/2085 |
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