lncRNA MIAT/HMGB1 Axis Is Involved in Cisplatin Resistance via Regulating IL6-Mediated Activation of the JAK2/STAT3 Pathway in Nasopharyngeal Carcinoma

lncRNA MIAT/HMGB1 Axis Is Involved in Cisplatin Resistance via Regulating IL6-Mediated Activation of the JAK2/STAT3 Pathway in Nasopharyngeal Carcinoma

Cisplatin-based chemotherapy and radiotherapy are the main first-line treatment strategies for nasopharyngeal carcinoma (NPC) patients. Unfortunately, resistance is a major obstacle in the clinical management of NPC patients. We prove that the expression level of high-mobility group box 1 (HMGB1) is...

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Bibliographic Details
Main Authors: Xuewei Zhu, Li Liu, Yang Wang, Jianan Cong, Zhang Lin, Yongsen Wang, Qi Liu, Leiming Wang, Ben Yang, Tao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
cisplatin resistance
HMGB1
IL6
NPC
lncRNA MIAT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.651693/full

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