MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

Summary: Recombination activating genes (RAGs), consisting of RAG1 and RAG2, are stringently regulated lymphoid-specific genes, which initiate V(D)J recombination in developing lymphocytes. We report the regulation of RAG1 through a microRNA (miRNA), miR-29c, in a B cell stage-specific manner in mic...

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Bibliographic Details
Main Authors: Rupa Kumari, Urbi Roy, Sagar Desai, Namrata M. Nilavar, Annemarie Van Nieuwenhuijze, Amita Paranjape, Gudapureddy Radha, Pushpinder Bawa, Mrinal Srivastava, Mridula Nambiar, Kithiganahalli Narayanaswamy Balaji, Adrian Liston, Bibha Choudhary, Sathees C. Raghavan
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
miRNA
RAG complex
immunoglobulin diversity
lymphoid system
B cell development
epigenetic regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007889

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