miRNA signature of mouse helper T cell hyper-proliferation.

miRNA signature of mouse helper T cell hyper-proliferation.

Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age. LAT Y136F mice carry a tyrosine to phenylalanine mutation in the Linker for Activation of T cells (LAT) gene. This mutation leads to a numbe...

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Bibliographic Details
Main Authors: Connie L Sommers, Alexandre K Rouquette-Jazdanian, Ana I Robles, Robert L Kortum, Robert K Merrill, Wenmei Li, Nandan Nath, Elizabeth Wohlfert, Katherine M Sixt, Yasmine Belkaid, Lawrence E Samelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3692518?pdf=render

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