Synthesizing existing evidence to design future trials: survey of methodologists from European institutions

• Main Authors: Adriani Nikolakopoulou, Sven Trelle, Alex J. Sutton, Matthias Egger, Georgia Salanti
• Format: Article
• Language: English
• Published: BMC 2019-06-01
• Series: Trials
• Subjects: Conditional trial design; Sample size; Meta-analysis; Network of interventions
• Online Access: http://link.springer.com/article/10.1186/s13063-019-3449-6

Abstract Background ‘Conditional trial design’ is a framework for efficiently planning new clinical trials based on a network of relevant existing trials. The framework considers whether new trials are required and how the existing evidence can be used to answer the research question and plan future research. The potential of this approach has not been fully realized. Methods We conducted an online survey among trial statisticians, methodologists, and users of evidence synthesis research using referral sampling to capture opinions about the conditional trial design framework and current practices among clinical researchers. The questions included in the survey were related to the decision of whether a meta-analysis answers the research question, the optimal way to synthesize available evidence, which relates to the acceptability of network meta-analysis, and the use of evidence synthesis in the planning of new studies. Results In total, 76 researchers completed the survey. Two out of three survey participants (65%) were willing to possibly or definitely consider using evidence synthesis to design a future clinical trial and around half of the participants would give priority to such a trial design. The median rating of the frequency of using such a trial design was 0.41 on a scale from 0 (never) to 1 (always). Major barriers to adopting conditional trial design include the current regulatory paradigm and the policies of funding agencies and sponsors. Conclusions Participants reported moderate interest in using evidence synthesis methods in the design of future trials. They indicated that a major paradigm shift is required before the use of network meta-analysis is regularly employed in the design of trials.