TRPC Channels in the SOCE Scenario
Transient receptor potential (TRP) proteins form non-selective Ca<sup>2+</sup> permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in <i>Drosophila</i>, it is well kno...
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doaj-b819076ab38b44a8a79c0834af9b14292020-11-25T02:05:26ZengMDPI AGCells2073-44092020-01-019112610.3390/cells9010126cells9010126TRPC Channels in the SOCE ScenarioJose J. Lopez0Isaac Jardin1Jose Sanchez-Collado2Ginés M. Salido3Tarik Smani4Juan A. Rosado5Department of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainDepartment of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainDepartment of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainDepartment of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainDepartment of Medical Physiology and Biophysics, Institute of Biomedicine of Sevilla, 41013 Sevilla, SpainDepartment of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, SpainTransient receptor potential (TRP) proteins form non-selective Ca<sup>2+</sup> permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in <i>Drosophila</i>, it is well known that these channels are activated by stimuli that induce PIP<sub>2</sub> hydrolysis. The canonical TRP (TRPC) channels have long been suggested to be constituents of the store-operated Ca<sup>2+</sup> (SOC) channels; however, none of the TRPC channels generate Ca<sup>2+</sup> currents that resemble <i>I</i><sub>CRAC</sub>. STIM1 and Orai1 have been identified as the components of the Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> (CRAC) channels and there is a body of evidence supporting that STIM1 is able to gate Orai1 and TRPC1 in order to mediate non-selective cation currents named <i>I</i><sub>SOC</sub>. STIM1 has been found to interact to and activate Orai1 and TRPC1 by different mechanisms and the involvement of TRPC1 in store-operated Ca<sup>2+</sup> entry requires both STIM1 and Orai1. In addition to the participation of TRPC1 in the <i>I</i><sub>SOC</sub> currents, TRPC1 and other TRPC proteins might play a relevant role modulating Orai1 channel function. This review summarizes the functional role of TRPC channels in the STIM1−Orai1 scenario.https://www.mdpi.com/2073-4409/9/1/126trpc1stim1orai1calcium influxstore-operated ca<sup>2+</sup> entry (soce) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jose J. Lopez Isaac Jardin Jose Sanchez-Collado Ginés M. Salido Tarik Smani Juan A. Rosado |
spellingShingle |
Jose J. Lopez Isaac Jardin Jose Sanchez-Collado Ginés M. Salido Tarik Smani Juan A. Rosado TRPC Channels in the SOCE Scenario Cells trpc1 stim1 orai1 calcium influx store-operated ca<sup>2+</sup> entry (soce) |
author_facet |
Jose J. Lopez Isaac Jardin Jose Sanchez-Collado Ginés M. Salido Tarik Smani Juan A. Rosado |
author_sort |
Jose J. Lopez |
title |
TRPC Channels in the SOCE Scenario |
title_short |
TRPC Channels in the SOCE Scenario |
title_full |
TRPC Channels in the SOCE Scenario |
title_fullStr |
TRPC Channels in the SOCE Scenario |
title_full_unstemmed |
TRPC Channels in the SOCE Scenario |
title_sort |
trpc channels in the soce scenario |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-01-01 |
description |
Transient receptor potential (TRP) proteins form non-selective Ca<sup>2+</sup> permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in <i>Drosophila</i>, it is well known that these channels are activated by stimuli that induce PIP<sub>2</sub> hydrolysis. The canonical TRP (TRPC) channels have long been suggested to be constituents of the store-operated Ca<sup>2+</sup> (SOC) channels; however, none of the TRPC channels generate Ca<sup>2+</sup> currents that resemble <i>I</i><sub>CRAC</sub>. STIM1 and Orai1 have been identified as the components of the Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> (CRAC) channels and there is a body of evidence supporting that STIM1 is able to gate Orai1 and TRPC1 in order to mediate non-selective cation currents named <i>I</i><sub>SOC</sub>. STIM1 has been found to interact to and activate Orai1 and TRPC1 by different mechanisms and the involvement of TRPC1 in store-operated Ca<sup>2+</sup> entry requires both STIM1 and Orai1. In addition to the participation of TRPC1 in the <i>I</i><sub>SOC</sub> currents, TRPC1 and other TRPC proteins might play a relevant role modulating Orai1 channel function. This review summarizes the functional role of TRPC channels in the STIM1−Orai1 scenario. |
topic |
trpc1 stim1 orai1 calcium influx store-operated ca<sup>2+</sup> entry (soce) |
url |
https://www.mdpi.com/2073-4409/9/1/126 |
work_keys_str_mv |
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