MITF and PAX3 play distinct roles in melanoma cell migration; outline of a genetic switch theory involving MITF and PAX3 in proliferative and invasive phenotypes of melanoma

MITF and PAX3 play distinct roles in melanoma cell migration; outline of a genetic switch theory involving MITF and PAX3 in proliferative and invasive phenotypes of melanoma

Melanoma is a very aggressive neoplasm with a propensity to undergo progression and invasion early in its evolution. The molecular pathways underpinning invasion in melanoma are now just beginning to be elucidated, but a clear understanding of the transition from non-invasive to invasive melanoma ce...

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Bibliographic Details
Main Authors: Michael R Eccles, Shujie eHe, Antonio eAhn, Lynn eSlobbe, Aaron R Jeffs, Han-Seung eYoon, Bruce C Baguley
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Oncology
Subjects:
Melanoma
Microphthalmia-Associated Transcription Factor
Paired Box Transcription Factors
migration and invasion
pax3
MITF
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00229/full

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