Rapid free thiol rebound is a physiological response following cold‐induced vasoconstriction in healthy humans, primary Raynaud and systemic sclerosis

Rapid free thiol rebound is a physiological response following cold‐induced vasoconstriction in healthy humans, primary Raynaud and systemic sclerosis

Abstract Raynaud's phenomenon (RP) is often the first sign of systemic sclerosis (SSc). Molecular mechanisms involved are incompletely understood, but reactive oxygen, nitrogen, and sulfur species are thought to play an important role in the pathogenesis of SSc. Free thiol groups play a protect...

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Bibliographic Details
Main Authors: Amaal Eman Abdulle, Anniek M. van Roon, Andries J. Smit, Andreas Pasch, Matijs vanMeurs, Hendrika Bootsma, Stephan J. L. Bakker, Mohammad Y. Said, Bernadette O. Fernandez, Martin Feelisch, Harry vanGoor, Douwe J. Mulder
Format: Article
Language:English
Published: Wiley 2019-03-01
Series:Physiological Reports
Subjects:
Free thiols
nitric oxide
Raynaud's phenomenon
redox system
systemic sclerosis
Online Access:https://doi.org/10.14814/phy2.14017

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