High-Density Lipoproteins and the Immune System
High-density lipoprotein (HDL) plays a major role in vasodilation and in the reduction of low-density lipoprotein (LDL) oxidation, inflammation, apoptosis, thrombosis, and infection; however, HDL is now less functional in these roles under certain conditions. This paper focuses on HDL, its anti-infl...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2013-01-01
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| Series: | Journal of Lipids |
| Online Access: | http://dx.doi.org/10.1155/2013/684903 |
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doaj-b8300f3a696047538443fe654ac284ce2020-11-25T00:12:19ZengHindawi LimitedJournal of Lipids2090-30302090-30492013-01-01201310.1155/2013/684903684903High-Density Lipoproteins and the Immune SystemHidesuke Kaji0Division of Physiology and Metabolism, University of Hyogo, 13-71 Kitaohji-cho, Akashi 673-8588, JapanHigh-density lipoprotein (HDL) plays a major role in vasodilation and in the reduction of low-density lipoprotein (LDL) oxidation, inflammation, apoptosis, thrombosis, and infection; however, HDL is now less functional in these roles under certain conditions. This paper focuses on HDL, its anti-inflammation behavior, and the mechanisms by which HDL interacts with components of the innate and adaptive immune systems. Genome-wide association studies (GWAS) and proteomic studies have elucidated important molecules involved in the interaction between HDL and the immune system. An understanding of these mechanisms is expected to be useful for the prevention and treatment of chronic inflammation due to metabolic syndrome, atherosclerosis, or various autoimmune diseases.http://dx.doi.org/10.1155/2013/684903 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hidesuke Kaji |
| spellingShingle |
Hidesuke Kaji High-Density Lipoproteins and the Immune System Journal of Lipids |
| author_facet |
Hidesuke Kaji |
| author_sort |
Hidesuke Kaji |
| title |
High-Density Lipoproteins and the Immune System |
| title_short |
High-Density Lipoproteins and the Immune System |
| title_full |
High-Density Lipoproteins and the Immune System |
| title_fullStr |
High-Density Lipoproteins and the Immune System |
| title_full_unstemmed |
High-Density Lipoproteins and the Immune System |
| title_sort |
high-density lipoproteins and the immune system |
| publisher |
Hindawi Limited |
| series |
Journal of Lipids |
| issn |
2090-3030 2090-3049 |
| publishDate |
2013-01-01 |
| description |
High-density lipoprotein (HDL) plays a major role in vasodilation and in the reduction of low-density lipoprotein (LDL) oxidation, inflammation, apoptosis, thrombosis, and infection; however, HDL is now less functional in these roles under certain conditions. This paper focuses on HDL, its anti-inflammation behavior, and the mechanisms by which HDL interacts with components of the innate and adaptive immune systems. Genome-wide association studies (GWAS) and proteomic studies have elucidated important molecules involved in the interaction between HDL and the immune system. An understanding of these mechanisms is expected to be useful for the prevention and treatment of chronic inflammation due to metabolic syndrome, atherosclerosis, or various autoimmune diseases. |
| url |
http://dx.doi.org/10.1155/2013/684903 |
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AT hidesukekaji highdensitylipoproteinsandtheimmunesystem |
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