Petasin and isopetasin reduce CGRP release from trigeminal afferents indicating an inhibitory effect on TRPA1 and TRPV1 receptor channels
Abstract Background Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. Calcitonin gene-related peptide (CGRP) is known as a biomarker and promoting factor of...
Main Authors: | Johanna Kleeberg-Hartmann, Birgit Vogler, Karl Messlinger |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-04-01
|
Series: | The Journal of Headache and Pain |
Subjects: | |
Online Access: | https://doi.org/10.1186/s10194-021-01235-5 |
Similar Items
-
Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells
by: Laura R. Sadofsky, et al.
Published: (2014-06-01) -
Effects of TRPA1 activation and inhibition on TRPA1 and CGRP expression in dorsal root ganglion neurons
by: Xiao-Lei Wang, et al.
Published: (2019-01-01) -
Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1
by: Mee-Ra Rhyu, et al.
Published: (2021-03-01) -
Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough
by: Li Long, et al.
Published: (2019-06-01) -
Increased expression of lung TRPV1/TRPA1 in a cough model of bleomycin-induced pulmonary fibrosis in Guinea pigs
by: Yali Guo, et al.
Published: (2019-02-01)