Synthesis, antioxidant and antimicrobial activity of carbohydrazones

• Main Authors: Božić Aleksandra R., Filipović Nenad R., Novaković Irena T., Bjelogrlić Snežana K., Nikolić Jasmina B., Drmanić Saša Ž., Marinković Aleksandar D.
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2017-01-01
• Series: Journal of the Serbian Chemical Society
• Subjects: carbohydrazones; antibacterial; antifungal; antioxidant activity; isomers
• Online Access: http://www.doiserbia.nb.rs/img/doi/0352-5139/2017/0352-51391700045B.pdf
• ISSN: 0352-5139; 1820-7421

Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide–water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172013]