p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tu...
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Bibliographic Details
Main Authors: |
Hye Yeon Choi,
Hifzur R. Siddique,
Mengmei Zheng,
Yi Kou,
Da-Wei Yeh,
Tatsuya Machida,
Chia-Lin Chen,
Dinesh Babu Uthaya Kumar,
Vasu Punj,
Peleg Winer,
Alejandro Pita,
Linda Sher,
Stanley M. Tahara,
Ratna B. Ray,
Chengyu Liang,
Lin Chen,
Hidekazu Tsukamoto,
Keigo Machida |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2020-06-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-020-16616-8
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