The Role of Adiponectin in Breast cancer: The mechanism and action
Adiponectin is one of the most important members of adipokine family which is widely synthesized and secreted by adipose tissue. The action of adiponectin is via binding to main receptors. It has several actions including regulation of glucose level, lipid homeostasis and reproductive system. Adip...
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Tehran University of Medical Sciences
2016-11-01
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doaj-b866bffc2d9842488179718918a2999e2021-04-04T07:07:00ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662016-11-0183The Role of Adiponectin in Breast cancer: The mechanism and actionRobab Sheikhpour0Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran Adiponectin is one of the most important members of adipokine family which is widely synthesized and secreted by adipose tissue. The action of adiponectin is via binding to main receptors. It has several actions including regulation of glucose level, lipid homeostasis and reproductive system. Adiponectin can also influence vascular endothelium via preventing the migration of monocytes. The role of adiponectin has been detected in progression of certain cancers associated with obesity. Obesity is a risk factor for breast cancer and develops the progression of breast cancer, since adipocytokines are produced exclusively by adipose tissue and may influence the association between obesity and breast cancer risk. Therefore, it seems that obesity can play important role in the pathogenesis of breast cancer. The mechanism of adiponectin action in breast cancer is currently unknown. It seems that adiponectin motivates the sensitivity of peripheral tissue to insulin. Insulin can motivate the proliferation of breast cancer cells via signaling through insulin and insulin –like growth factor (IGF-1) receptors. Also insulin may upregulate a potent angiogenic agent including vascular endothelial growth factor (VEGF) expression that is secreted by breast cancer cells. https://bccr.tums.ac.ir/index.php/bccrj/article/view/213Adiponectinbreast cancermechanismaction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robab Sheikhpour |
spellingShingle |
Robab Sheikhpour The Role of Adiponectin in Breast cancer: The mechanism and action Basic & Clinical Cancer Research Adiponectin breast cancer mechanism action |
author_facet |
Robab Sheikhpour |
author_sort |
Robab Sheikhpour |
title |
The Role of Adiponectin in Breast cancer: The mechanism and action |
title_short |
The Role of Adiponectin in Breast cancer: The mechanism and action |
title_full |
The Role of Adiponectin in Breast cancer: The mechanism and action |
title_fullStr |
The Role of Adiponectin in Breast cancer: The mechanism and action |
title_full_unstemmed |
The Role of Adiponectin in Breast cancer: The mechanism and action |
title_sort |
role of adiponectin in breast cancer: the mechanism and action |
publisher |
Tehran University of Medical Sciences |
series |
Basic & Clinical Cancer Research |
issn |
2228-6527 2228-5466 |
publishDate |
2016-11-01 |
description |
Adiponectin is one of the most important members of adipokine family which is widely synthesized and secreted by adipose tissue. The action of adiponectin is via binding to main receptors. It has several actions including regulation of glucose level, lipid homeostasis and reproductive system. Adiponectin can also influence vascular endothelium via preventing the migration of monocytes. The role of adiponectin has been detected in progression of certain cancers associated with obesity. Obesity is a risk factor for breast cancer and develops the progression of breast cancer, since adipocytokines are produced exclusively by adipose tissue and may influence the association between obesity and breast cancer risk. Therefore, it seems that obesity can play important role in the pathogenesis of breast cancer. The mechanism of adiponectin action in breast cancer is currently unknown. It seems that adiponectin motivates the sensitivity of peripheral tissue to insulin. Insulin can motivate the proliferation of breast cancer cells via signaling through insulin and insulin –like growth factor (IGF-1) receptors. Also insulin may upregulate a potent angiogenic agent including vascular endothelial growth factor (VEGF) expression that is secreted by breast cancer cells.
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topic |
Adiponectin breast cancer mechanism action |
url |
https://bccr.tums.ac.ir/index.php/bccrj/article/view/213 |
work_keys_str_mv |
AT robabsheikhpour theroleofadiponectininbreastcancerthemechanismandaction AT robabsheikhpour roleofadiponectininbreastcancerthemechanismandaction |
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