Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria
Predictors for glucose intolerance postpartum were evaluated in women with gestational diabetes mellitus (GDM) based on the 2013 World Health Organization (WHO) criteria. 1841 women were tested for GDM in a prospective cohort study. A postpartum 75g oral glucose tolerance test (OGTT) was performed i...
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doaj-b87e34a6c4d74780b1d6d848445128752020-11-25T02:56:09ZengMDPI AGJournal of Clinical Medicine2077-03832019-03-018338310.3390/jcm8030383jcm8030383Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO CriteriaKatrien Benhalima0Paul Van Crombrugge1Carolien Moyson2Johan Verhaeghe3Sofie Vandeginste4Hilde Verlaenen5Chris Vercammen6Toon Maes7Els Dufraimont8Christophe De Block9Yves Jacquemyn10Farah Mekahli11Katrien De Clippel12Annick Van Den Bruel13Anne Loccufier14Annouschka Laenen15Caro Minschart16Roland Devlieger17Chantal Mathieu18Department of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, BelgiumDepartment of Endocrinology, OLV Ziekenhuis Aalst-Asse-Ninove, Moorselbaan 164, 9300 Aalst, BelgiumDepartment of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, BelgiumDepartment of Obstetrics & Gynecology, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, BelgiumDepartment of Obstetrics & Gynecology, OLV Ziekenhuis Aalst-Asse-Ninove, Moorselbaan 164, 9300 Aalst, BelgiumDepartment of Obstetrics & Gynecology, OLV Ziekenhuis Aalst-Asse-Ninove, Moorselbaan 164, 9300 Aalst, BelgiumDepartment of Endocrinology, Imelda Ziekenhuis, Imeldalaan 9, 2820 Bonheiden, BelgiumDepartment of Endocrinology, Imelda Ziekenhuis, Imeldalaan 9, 2820 Bonheiden, BelgiumDepartment of Obstetrics & Gynecology, Imelda Ziekenhuis, Imeldalaan 9, 2820 Bonheiden, BelgiumDepartment of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, Wilrijkstraat 10, 2560 Edegem, BelgiumDepartment of Obstetrics & Gynecology, Antwerp University Hospital, Wilrijkstraat 10, 2560 Edegem, BelgiumDepartment of Endocrinology, Kliniek St-Jan Brussel, Kruidtuinlaan 32, 1000 Brussel, BelgiumDepartment of Obstetrics & Gynecology, Kliniek St-Jan Brussel, Kruidtuinlaan 32, 1000 Brussel, BelgiumDepartment of Endocrinology, AZ St Jan Brugge, Ruddershove 10, 8000 Brugge, BelgiumDepartment of Obstetrics & Gynecology, AZ St Jan Brugge, Ruddershove 10, 8000 Brugge, BelgiumCenter of Biostatics and Statistical bioinformatics, KU Leuven, Kapucijnenvoer 35 bloc d—box 7001, 3000 Leuven, BelgiumDepartment of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, BelgiumDepartment of Obstetrics & Gynecology, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, BelgiumDepartment of Endocrinology, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, BelgiumPredictors for glucose intolerance postpartum were evaluated in women with gestational diabetes mellitus (GDM) based on the 2013 World Health Organization (WHO) criteria. 1841 women were tested for GDM in a prospective cohort study. A postpartum 75g oral glucose tolerance test (OGTT) was performed in women with GDM at 14 ± 4.1 weeks. Of all 231 mothers with GDM, 83.1% (192) had a postpartum OGTT of which 18.2% (35) had glucose intolerance. Women with glucose intolerance were more often of Asian origin [15.1% vs. 3.7%, OR 4.64 (1.26–17.12)], had more often a recurrent history of GDM [41.7% vs. 26.7%, OR 3.68 (1.37–9.87)], higher fasting glycaemia (FPG) [5.1 (4.5–5.3) vs. 4.6 (4.3–5.1) mmol/L, OR 1.05 (1.01–1.09)], higher HbA1c [33 (31–36) vs. 32 (30–33) mmol/mol, OR 4.89 (1.61–14.82)], and higher triglycerides [2.2 (1.9–2.8) vs. 2.0 (1.6–2.5) mmol/L, OR 1.00 (1.00–1.01)]. Sensitivity of glucose challenge test (GCT) ≥7.2 mmol/l for glucose intolerance postpartum was 80% (63.1%–91.6%). The area under the curve to predict glucose intolerance was 0.76 (0.65–0.87) for FPG, 0.54 (0.43–0.65) for HbA1c and 0.75 (0.64–0.86) for both combined. In conclusion, nearly one-fifth of women with GDM have glucose intolerance postpartum. A GCT ≥7.2 mmol/L identifies a high risk population for glucose intolerance postpartum.http://www.mdpi.com/2077-0383/8/3/383glucose intolerancepostpartumgestational diabetes mellitus2013 WHO criteriarisk factorsprediction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katrien Benhalima Paul Van Crombrugge Carolien Moyson Johan Verhaeghe Sofie Vandeginste Hilde Verlaenen Chris Vercammen Toon Maes Els Dufraimont Christophe De Block Yves Jacquemyn Farah Mekahli Katrien De Clippel Annick Van Den Bruel Anne Loccufier Annouschka Laenen Caro Minschart Roland Devlieger Chantal Mathieu |
spellingShingle |
Katrien Benhalima Paul Van Crombrugge Carolien Moyson Johan Verhaeghe Sofie Vandeginste Hilde Verlaenen Chris Vercammen Toon Maes Els Dufraimont Christophe De Block Yves Jacquemyn Farah Mekahli Katrien De Clippel Annick Van Den Bruel Anne Loccufier Annouschka Laenen Caro Minschart Roland Devlieger Chantal Mathieu Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria Journal of Clinical Medicine glucose intolerance postpartum gestational diabetes mellitus 2013 WHO criteria risk factors prediction |
author_facet |
Katrien Benhalima Paul Van Crombrugge Carolien Moyson Johan Verhaeghe Sofie Vandeginste Hilde Verlaenen Chris Vercammen Toon Maes Els Dufraimont Christophe De Block Yves Jacquemyn Farah Mekahli Katrien De Clippel Annick Van Den Bruel Anne Loccufier Annouschka Laenen Caro Minschart Roland Devlieger Chantal Mathieu |
author_sort |
Katrien Benhalima |
title |
Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_short |
Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_full |
Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_fullStr |
Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_full_unstemmed |
Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_sort |
prediction of glucose intolerance in early postpartum in women with gestational diabetes mellitus based on the 2013 who criteria |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-03-01 |
description |
Predictors for glucose intolerance postpartum were evaluated in women with gestational diabetes mellitus (GDM) based on the 2013 World Health Organization (WHO) criteria. 1841 women were tested for GDM in a prospective cohort study. A postpartum 75g oral glucose tolerance test (OGTT) was performed in women with GDM at 14 ± 4.1 weeks. Of all 231 mothers with GDM, 83.1% (192) had a postpartum OGTT of which 18.2% (35) had glucose intolerance. Women with glucose intolerance were more often of Asian origin [15.1% vs. 3.7%, OR 4.64 (1.26–17.12)], had more often a recurrent history of GDM [41.7% vs. 26.7%, OR 3.68 (1.37–9.87)], higher fasting glycaemia (FPG) [5.1 (4.5–5.3) vs. 4.6 (4.3–5.1) mmol/L, OR 1.05 (1.01–1.09)], higher HbA1c [33 (31–36) vs. 32 (30–33) mmol/mol, OR 4.89 (1.61–14.82)], and higher triglycerides [2.2 (1.9–2.8) vs. 2.0 (1.6–2.5) mmol/L, OR 1.00 (1.00–1.01)]. Sensitivity of glucose challenge test (GCT) ≥7.2 mmol/l for glucose intolerance postpartum was 80% (63.1%–91.6%). The area under the curve to predict glucose intolerance was 0.76 (0.65–0.87) for FPG, 0.54 (0.43–0.65) for HbA1c and 0.75 (0.64–0.86) for both combined. In conclusion, nearly one-fifth of women with GDM have glucose intolerance postpartum. A GCT ≥7.2 mmol/L identifies a high risk population for glucose intolerance postpartum. |
topic |
glucose intolerance postpartum gestational diabetes mellitus 2013 WHO criteria risk factors prediction |
url |
http://www.mdpi.com/2077-0383/8/3/383 |
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