Intact CD100–CD72 Interaction Necessary for TCR-Induced T Cell Proliferation

Targeting CD100 by antibody blockade is a potential therapeutic strategy for cancers, but the functional effects on T cells following blockade of this immune activating molecule are rarely considered. Indeed, CD100 is highly expressed in T cells and anti-CD100 antibodies play a role during T cell pr...

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Bibliographic Details
Main Authors: Xiaojun Jiang, Niklas K. Björkström, Espen Melum
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00765/full