Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemia
Background Bleeding, one of the most common symptoms of acute leukemia in untreated patients, is mostly due to thrombocy- topenia as a result of myeloinvasion by leukemic cells. Neverthe- less, a further contributory factor for the additional hemorrhagic complication during intensive chemotherapy is...
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doaj-b88583d1258d4b07805711edb9b3bbdb2020-11-24T21:18:26ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-01461465010.14238/pi46.1.2006.46-50716Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemiaDjajadiman GatotKeumala PringgardiniRulina SuradiBackground Bleeding, one of the most common symptoms of acute leukemia in untreated patients, is mostly due to thrombocy- topenia as a result of myeloinvasion by leukemic cells. Neverthe- less, a further contributory factor for the additional hemorrhagic complication during intensive chemotherapy is the myelosuppressive effect of most active drugs. L-asparaginase, one of the cytostatics used during remission induction therapy for childhood of acute lymphoblastic leukemia (ALL), is widely reported to impair the he- mostatic system. Objective To determine the influence of shorter courses of L-as- paraginase (L-Ase) on some of the hemostatic parameters in the treatment of childhood ALL. Methods A prospective analytical study was carried out in the Department of Child Health, Cipto Mangunkusumo Hospital Jakarta from July 1, 1999 to June 30, 2001 on newly diagnosed ALL pa- tients with normal liver function tests treated according to our na- tional ALL protocol which one of its composition contained 6 in- stead of 9 injections of L-asparaginase. Results All of 30 children with ALL included in the study, experi- enced prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), and decreased fibrinogen concentra- tion, markedly during the administration of L-asparaginase. How- ever, none of the patients had additional hemorrhage or evidence of disseminated intravascular coagulation (DIC). Conclusion The use of shorter courses of L-asparaginase, 6 in- jections, in the remission induction chemotherapy of childhood ALL in our department may reduce the blood clotting factors without further hemorrhage complication or evidence of DIChttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/854L-asparaginasechildhood ALLcoagulationbleeding |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Djajadiman Gatot Keumala Pringgardini Rulina Suradi |
spellingShingle |
Djajadiman Gatot Keumala Pringgardini Rulina Suradi Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemia Paediatrica Indonesiana L-asparaginase childhood ALL coagulation bleeding |
author_facet |
Djajadiman Gatot Keumala Pringgardini Rulina Suradi |
author_sort |
Djajadiman Gatot |
title |
Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemia |
title_short |
Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemia |
title_full |
Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemia |
title_fullStr |
Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemia |
title_full_unstemmed |
Coagulation abnormality as a complication of L-asparaginase therapy in childhood lymphoblastic leukemia |
title_sort |
coagulation abnormality as a complication of l-asparaginase therapy in childhood lymphoblastic leukemia |
publisher |
Indonesian Pediatric Society Publishing House |
series |
Paediatrica Indonesiana |
issn |
0030-9311 2338-476X |
publishDate |
2016-10-01 |
description |
Background Bleeding, one of the most common symptoms of
acute leukemia in untreated patients, is mostly due to thrombocy-
topenia as a result of myeloinvasion by leukemic cells. Neverthe-
less, a further contributory factor for the additional hemorrhagic
complication during intensive chemotherapy is the myelosuppressive
effect of most active drugs. L-asparaginase, one of the cytostatics
used during remission induction therapy for childhood of acute
lymphoblastic leukemia (ALL), is widely reported to impair the he-
mostatic system.
Objective To determine the influence of shorter courses of L-as-
paraginase (L-Ase) on some of the hemostatic parameters in the
treatment of childhood ALL.
Methods A prospective analytical study was carried out in the
Department of Child Health, Cipto Mangunkusumo Hospital Jakarta
from July 1, 1999 to June 30, 2001 on newly diagnosed ALL pa-
tients with normal liver function tests treated according to our na-
tional ALL protocol which one of its composition contained 6 in-
stead of 9 injections of L-asparaginase.
Results All of 30 children with ALL included in the study, experi-
enced prolongation of prothrombin time (PT), activated partial
thromboplastin time (aPTT), and decreased fibrinogen concentra-
tion, markedly during the administration of L-asparaginase. How-
ever, none of the patients had additional hemorrhage or evidence
of disseminated intravascular coagulation (DIC).
Conclusion The use of shorter courses of L-asparaginase, 6 in-
jections, in the remission induction chemotherapy of childhood ALL
in our department may reduce the blood clotting factors without
further hemorrhage complication or evidence of DIC |
topic |
L-asparaginase childhood ALL coagulation bleeding |
url |
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/854 |
work_keys_str_mv |
AT djajadimangatot coagulationabnormalityasacomplicationoflasparaginasetherapyinchildhoodlymphoblasticleukemia AT keumalapringgardini coagulationabnormalityasacomplicationoflasparaginasetherapyinchildhoodlymphoblasticleukemia AT rulinasuradi coagulationabnormalityasacomplicationoflasparaginasetherapyinchildhoodlymphoblasticleukemia |
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1726009238581411840 |