Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis

Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis

The stem bark of Phoebe grandis afforded one new oxoproaporphine; (–)-grandine A (1), along with six known isoquinoline alkaloids: (–)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR...

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Bibliographic Details
Main Authors: Khalijah Awang, Marc Litaudon, Noel F. Thomas, A. Hamid A. Hadi, Ahmad Nazif Aziz, Mat Ropi Mukhtar
Format: Article
Language:English
Published: MDPI AG 2009-03-01
Series:Molecules
Subjects:
Oxoproaporphine
NMR
Phoebe grandis
Aporphine
Dihydrolinearisine
Online Access:http://www.mdpi.com/1420-3049/14/3/1227/
Description
Summary:The stem bark of Phoebe grandis afforded one new oxoproaporphine; (–)-grandine A (1), along with six known isoquinoline alkaloids: (–)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (–)-8,9-dihydrolinearisine (2) is also reported. The alkaloids’ structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.
ISSN:1420-3049

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