TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma
Tubulin polymerization promoting protein family member 3 (TPPP3) is a kind of protein that can mediate the dynamics and stability of microtubules. However, the correlations of TPPP3 between prognosis and immune infiltrates in different tumors are still unclear. The analysis of TPPP3 expression was p...
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doaj-b88edb67944c4f3bb035b56cbb5770f42020-11-25T03:56:37ZengHindawi LimitedBioMed Research International2314-61332314-61412020-01-01202010.1155/2020/39621463962146TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous CarcinomaZheng Yang0Xiaohong Li1Jingyu Li2Qisheng Su3Yuling Qiu4Zunni Zhang5Liqian Zhang6Wuning Mo7Department of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Otorhinolaryngology and Head and Neck Surgery, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, ChinaTubulin polymerization promoting protein family member 3 (TPPP3) is a kind of protein that can mediate the dynamics and stability of microtubules. However, the correlations of TPPP3 between prognosis and immune infiltrates in different tumors are still unclear. The analysis of TPPP3 expression was performed via Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) website. We also used GEPIA to assess the impact of TPPPT3 on clinical outcomes. The related pathways involved in TPPP3 were analyzed by gene-set enrichment analysis (GSEA), and the correlation between TPPP3 and immune infiltration was studied by Tumor Immune Estimation Resource2.0 (TIMER 2.0). The TPPP3 expression was significantly reduced in head and neck squamous carcinoma (HNSC) compared to adjacent tissues. In addition, the low expression of TPPP3 in HNSC was significantly associated with prognosis. The pathways closely related to the low expression of TPPP3 are “Antigen Processing and Presentation,” “Primary Immunodeficiency,” and so on. The TPPP3 expression was negatively correlated with the level of CD8+ T cell, B cell, and myeloid dendritic cell infiltration in HNSC. The TPPP3 expression is closely related to multiple immunomarkers in CD8+ T cell and Myeloid dendritic cells. These data indicate that TPPP3 is associated with multiple cancers and involves multiple immune-related pathways, and TPPP3 is associated with immune infiltration levels. Besides, the TPPP3 expression may help regulate tumor-associated CD8 + T cells, DC cells in HNSC. We conclude TPPP3 can be considered as a biomarker for predicting head and neck squamous cell carcinoma prognosis and immune infiltration.http://dx.doi.org/10.1155/2020/3962146 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zheng Yang Xiaohong Li Jingyu Li Qisheng Su Yuling Qiu Zunni Zhang Liqian Zhang Wuning Mo |
spellingShingle |
Zheng Yang Xiaohong Li Jingyu Li Qisheng Su Yuling Qiu Zunni Zhang Liqian Zhang Wuning Mo TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma BioMed Research International |
author_facet |
Zheng Yang Xiaohong Li Jingyu Li Qisheng Su Yuling Qiu Zunni Zhang Liqian Zhang Wuning Mo |
author_sort |
Zheng Yang |
title |
TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma |
title_short |
TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma |
title_full |
TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma |
title_fullStr |
TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma |
title_full_unstemmed |
TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma |
title_sort |
tppp3 associated with prognosis and immune infiltrates in head and neck squamous carcinoma |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2020-01-01 |
description |
Tubulin polymerization promoting protein family member 3 (TPPP3) is a kind of protein that can mediate the dynamics and stability of microtubules. However, the correlations of TPPP3 between prognosis and immune infiltrates in different tumors are still unclear. The analysis of TPPP3 expression was performed via Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) website. We also used GEPIA to assess the impact of TPPPT3 on clinical outcomes. The related pathways involved in TPPP3 were analyzed by gene-set enrichment analysis (GSEA), and the correlation between TPPP3 and immune infiltration was studied by Tumor Immune Estimation Resource2.0 (TIMER 2.0). The TPPP3 expression was significantly reduced in head and neck squamous carcinoma (HNSC) compared to adjacent tissues. In addition, the low expression of TPPP3 in HNSC was significantly associated with prognosis. The pathways closely related to the low expression of TPPP3 are “Antigen Processing and Presentation,” “Primary Immunodeficiency,” and so on. The TPPP3 expression was negatively correlated with the level of CD8+ T cell, B cell, and myeloid dendritic cell infiltration in HNSC. The TPPP3 expression is closely related to multiple immunomarkers in CD8+ T cell and Myeloid dendritic cells. These data indicate that TPPP3 is associated with multiple cancers and involves multiple immune-related pathways, and TPPP3 is associated with immune infiltration levels. Besides, the TPPP3 expression may help regulate tumor-associated CD8 + T cells, DC cells in HNSC. We conclude TPPP3 can be considered as a biomarker for predicting head and neck squamous cell carcinoma prognosis and immune infiltration. |
url |
http://dx.doi.org/10.1155/2020/3962146 |
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