Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, wit...

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Bibliographic Details
Main Authors: Rieke Martens, Marc Permanyer, Kathrin Werth, Kai Yu, Asolina Braun, Olga Halle, Stephan Halle, Gwendolyn E. Patzer, Berislav Bošnjak, Friedemann Kiefer, Anika Janssen, Michaela Friedrichsen, Jenny Poetzsch, Karan Kohli, Yvonne Lueder, Rodrigo Gutierrez Jauregui, Nadine Eckert, Tim Worbs, Melanie Galla, Reinhold Förster
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14921-w

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