Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer
As couples are increasingly delaying parenthood, the effect of the aging men and women on reproductive outcomes has been an area of increased interest. Advanced paternal age has been shown to independently affect the entire spectrum of male fertility as assessed by reductions in sperm quality and fe...
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Wolters Kluwer Medknow Publications
2016-01-01
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doaj-b89a5fa65d184b4b8eeea1d1dd6b5e872020-11-24T22:24:32ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622016-01-0118342042410.4103/1008-682X.175097Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancerSimon L ContiMichael L EisenbergAs couples are increasingly delaying parenthood, the effect of the aging men and women on reproductive outcomes has been an area of increased interest. Advanced paternal age has been shown to independently affect the entire spectrum of male fertility as assessed by reductions in sperm quality and fertilization (both assisted and unassisted). Moreover, epidemiological data suggest that paternal age can lead to higher rates of adverse birth outcomes and congenital anomalies. Mounting evidence also suggests increased risk of specific pediatric and adult disease states ranging from cancer to behavioral traits. While disease states associated with advancing paternal age have been well described, consensus recommendations for neonatal screening have not been as widely implemented as have been with advanced maternal age.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=3;spage=420;epage=424;aulast=Contifertilization; paternal aging; semen quality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Simon L Conti Michael L Eisenberg |
spellingShingle |
Simon L Conti Michael L Eisenberg Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer Asian Journal of Andrology fertilization; paternal aging; semen quality |
author_facet |
Simon L Conti Michael L Eisenberg |
author_sort |
Simon L Conti |
title |
Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer |
title_short |
Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer |
title_full |
Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer |
title_fullStr |
Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer |
title_full_unstemmed |
Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer |
title_sort |
paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Journal of Andrology |
issn |
1008-682X 1745-7262 |
publishDate |
2016-01-01 |
description |
As couples are increasingly delaying parenthood, the effect of the aging men and women on reproductive outcomes has been an area of increased interest. Advanced paternal age has been shown to independently affect the entire spectrum of male fertility as assessed by reductions in sperm quality and fertilization (both assisted and unassisted). Moreover, epidemiological data suggest that paternal age can lead to higher rates of adverse birth outcomes and congenital anomalies. Mounting evidence also suggests increased risk of specific pediatric and adult disease states ranging from cancer to behavioral traits. While disease states associated with advancing paternal age have been well described, consensus recommendations for neonatal screening have not been as widely implemented as have been with advanced maternal age. |
topic |
fertilization; paternal aging; semen quality |
url |
http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=3;spage=420;epage=424;aulast=Conti |
work_keys_str_mv |
AT simonlconti paternalagingandincreasedriskofcongenitaldiseasepsychiatricdisordersandcancer AT michaelleisenberg paternalagingandincreasedriskofcongenitaldiseasepsychiatricdisordersandcancer |
_version_ |
1725760814356365312 |