Blood Outgrowth Endothelial Cells as a Cellular Carrier for Oncolytic Vesicular Stomatitis Virus Expressing Interferon-β in Preclinical Models of Non-Small Cell Lung Cancer

Blood Outgrowth Endothelial Cells as a Cellular Carrier for Oncolytic Vesicular Stomatitis Virus Expressing Interferon-β in Preclinical Models of Non-Small Cell Lung Cancer

Oncolytic viruses have demonstrated efficacy in numerous tumor models including non-small cell lung cancer (NSCLC). One limitation of viral therapy for metastatic lung cancer is that systemic administration can be hindered by complement and antiviral immunity. Thus, we investigated whether ex vivo-i...

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Bibliographic Details
Main Authors: Manish R. Patel, Blake A. Jacobson, Yan Ji, Robert P. Hebbel, Robert A. Kratzke
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320302631

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