The era of bioengineering: how will this affect the next generation of cancer immunotherapy?
Abstract Background Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the immune system against tumors, from the administrati...
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doaj-b8a78771410746d2b2c11f5179f4c7b52020-11-25T00:51:50ZengBMCJournal of Translational Medicine1479-58762017-06-0115111610.1186/s12967-017-1244-2The era of bioengineering: how will this affect the next generation of cancer immunotherapy?Michele Graciotti0Cristiana Berti1Harm-Anton Klok2Lana Kandalaft3Center of Experimental Therapeutics, Department of Oncology, University Hospital of LausanneLaboratoire des Polymères, Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), Bâtiment MXDLaboratoire des Polymères, Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), Bâtiment MXDCenter of Experimental Therapeutics, Department of Oncology, University Hospital of LausanneAbstract Background Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the immune system against tumors, from the administration of immunomodulatory agents that activate immune cells, to therapeutic vaccines or infusion of previously activated cancer-specific T cells. However, despite great recent progress many difficulties still remain, which prevent the widespread use of immunotherapy. Some of these limitations include: systemic toxicity, weak immune cellular responses or persistence over time and most ultimately costly and time-consuming procedures. Main body Synthetic and natural biomaterials hold great potential to address these hurdles providing biocompatible systems capable of targeted local delivery, co-delivery, and controlled and/or sustained release. In this review we discuss some of the bioengineered solutions and approaches developed so far and how biomaterials can be further implemented to help and shape the future of cancer immunotherapy. Conclusion The bioengineering strategies here presented constitute a powerful toolkit to develop safe and successful novel cancer immunotherapies.http://link.springer.com/article/10.1186/s12967-017-1244-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michele Graciotti Cristiana Berti Harm-Anton Klok Lana Kandalaft |
spellingShingle |
Michele Graciotti Cristiana Berti Harm-Anton Klok Lana Kandalaft The era of bioengineering: how will this affect the next generation of cancer immunotherapy? Journal of Translational Medicine |
author_facet |
Michele Graciotti Cristiana Berti Harm-Anton Klok Lana Kandalaft |
author_sort |
Michele Graciotti |
title |
The era of bioengineering: how will this affect the next generation of cancer immunotherapy? |
title_short |
The era of bioengineering: how will this affect the next generation of cancer immunotherapy? |
title_full |
The era of bioengineering: how will this affect the next generation of cancer immunotherapy? |
title_fullStr |
The era of bioengineering: how will this affect the next generation of cancer immunotherapy? |
title_full_unstemmed |
The era of bioengineering: how will this affect the next generation of cancer immunotherapy? |
title_sort |
era of bioengineering: how will this affect the next generation of cancer immunotherapy? |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2017-06-01 |
description |
Abstract Background Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the immune system against tumors, from the administration of immunomodulatory agents that activate immune cells, to therapeutic vaccines or infusion of previously activated cancer-specific T cells. However, despite great recent progress many difficulties still remain, which prevent the widespread use of immunotherapy. Some of these limitations include: systemic toxicity, weak immune cellular responses or persistence over time and most ultimately costly and time-consuming procedures. Main body Synthetic and natural biomaterials hold great potential to address these hurdles providing biocompatible systems capable of targeted local delivery, co-delivery, and controlled and/or sustained release. In this review we discuss some of the bioengineered solutions and approaches developed so far and how biomaterials can be further implemented to help and shape the future of cancer immunotherapy. Conclusion The bioengineering strategies here presented constitute a powerful toolkit to develop safe and successful novel cancer immunotherapies. |
url |
http://link.springer.com/article/10.1186/s12967-017-1244-2 |
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