Learning and survival memory undergoing a permanent bilateral carotid ligation in rats

• Main Authors: Maria Cecília Santos Cavalcanti Melo, Diego Gadelha, Guilherme Veras Mascena, Thárcia Kiara Beserra Oliveira, Carlos Teixeira Brandt
• Format: Article
• Language: English
• Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2013-02-01
• Series: Acta Cirurgica Brasileira
• Subjects: Hypoxia-Ischemia, Brain; Carotid Arteries; Memory Disorders; Rats
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000200003

PURPOSE: To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL). METHODS: Twenty-four survivors of PBCL were evaluated after 30 days with regard to memory and learning using a water survival maze. Twenty-three healthy rats were used as control group. The results were expressed by their means and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee for animal investigation. RESULTS: The mortality rate for the surgery was 44.4%. The latency time to find the survival platform was higher in rats that underwent PBCL (Normal: 10.24 ± 1.85s - Study: 25.30 ± 4.69s - Mann - Whitney p=0.0388). Additionally, the type of swimming and the spatial stability of the studied rats on the survival platform were compromised in these animals. CONCLUSION: The permanent bilateral carotid ligation induces change in the learning and survival memory.