Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation
The effects of astaxanthin supplementation on visceral adipose tissue and lipid profile in an Otsuka Long Evans Tokushima Fatty (OLETF) rat model of hyperphagia and visceral fat accumulation was investigated. At 25 weeks of age, OLETF rats were assigned randomly to an obese control (OC, n = 6) or an...
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doaj-b8b40f202d29495cb71bac347301d8672021-04-29T04:42:56ZengElsevierJournal of Functional Foods1756-46462014-11-0111114120Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulationMasaki Kimura0Mayuko Iida1Hideki Yamauchi2Masato Suzuki3Toshiaki Shibasaki4Yoshimasa Saito5Hidetsugu Saito6Department of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; Department of Metabolic Medicine, Mater Medical Research Institute, University of Queensland, 37 Kent Street, Woolloongabba, Queensland 4102, Australia; Corresponding author. Department of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. Tel.: +81 3 5400 2692; fax: +81 3 5400 2692.Department of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, JapanDepartment of Molecular Physiology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, JapanDepartment of Laboratory Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, JapanDepartment of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, JapanDepartment of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, JapanDepartment of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, JapanThe effects of astaxanthin supplementation on visceral adipose tissue and lipid profile in an Otsuka Long Evans Tokushima Fatty (OLETF) rat model of hyperphagia and visceral fat accumulation was investigated. At 25 weeks of age, OLETF rats were assigned randomly to an obese control (OC, n = 6) or an astaxanthin supplementation (AX, n = 6) group. Long Evans Tokushima Otsuka (LETO) rats were assigned to a lean control (LT, n = 6) group. The AX group was subjected to 6 weeks of dietary supplementation with 0.2% astaxanthin (2 g/kg diet powder chow food) ad libitum. After the 6-week experimental period, astaxanthin supplementation in obese rats promoted size reduction of visceral adipocytes, with a remarkable decrease in FFA and a significant increase in blood HDL-c concentrations. These results suggest that astaxanthin can at least partially ameliorate lipid profile and adipocyte abnormalities associated with obesity.http://www.sciencedirect.com/science/article/pii/S1756464614002497AstaxanthinSupplementationVisceral fatAdipocyte sizeLipid profileLipid oxidation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masaki Kimura Mayuko Iida Hideki Yamauchi Masato Suzuki Toshiaki Shibasaki Yoshimasa Saito Hidetsugu Saito |
spellingShingle |
Masaki Kimura Mayuko Iida Hideki Yamauchi Masato Suzuki Toshiaki Shibasaki Yoshimasa Saito Hidetsugu Saito Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation Journal of Functional Foods Astaxanthin Supplementation Visceral fat Adipocyte size Lipid profile Lipid oxidation |
author_facet |
Masaki Kimura Mayuko Iida Hideki Yamauchi Masato Suzuki Toshiaki Shibasaki Yoshimasa Saito Hidetsugu Saito |
author_sort |
Masaki Kimura |
title |
Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation |
title_short |
Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation |
title_full |
Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation |
title_fullStr |
Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation |
title_full_unstemmed |
Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation |
title_sort |
astaxanthin supplementation effects on adipocyte size and lipid profile in oletf rats with hyperphagia and visceral fat accumulation |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2014-11-01 |
description |
The effects of astaxanthin supplementation on visceral adipose tissue and lipid profile in an Otsuka Long Evans Tokushima Fatty (OLETF) rat model of hyperphagia and visceral fat accumulation was investigated. At 25 weeks of age, OLETF rats were assigned randomly to an obese control (OC, n = 6) or an astaxanthin supplementation (AX, n = 6) group. Long Evans Tokushima Otsuka (LETO) rats were assigned to a lean control (LT, n = 6) group. The AX group was subjected to 6 weeks of dietary supplementation with 0.2% astaxanthin (2 g/kg diet powder chow food) ad libitum. After the 6-week experimental period, astaxanthin supplementation in obese rats promoted size reduction of visceral adipocytes, with a remarkable decrease in FFA and a significant increase in blood HDL-c concentrations. These results suggest that astaxanthin can at least partially ameliorate lipid profile and adipocyte abnormalities associated with obesity. |
topic |
Astaxanthin Supplementation Visceral fat Adipocyte size Lipid profile Lipid oxidation |
url |
http://www.sciencedirect.com/science/article/pii/S1756464614002497 |
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