Myocardial tissue characterisation using echocardiographic deformation imaging

Abstract Myocardial pathology results in significant morbidity and mortality, whether due to primary cardiomyopathic processes or secondary to other conditions such as ischemic heart disease. Cardiac imaging techniques characterise the underlying tissue directly, by assessing a signal from the tissu...

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Main Authors: Mohammed A. Moharram, Regis R. Lamberts, Gillian Whalley, Michael J. A. Williams, Sean Coffey
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cardiovascular Ultrasound
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12947-019-0176-9
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spelling doaj-b8bc837e1d07480794d972b09ca9b6fa2020-11-25T04:07:19ZengBMCCardiovascular Ultrasound1476-71202019-11-0117111110.1186/s12947-019-0176-9Myocardial tissue characterisation using echocardiographic deformation imagingMohammed A. Moharram0Regis R. Lamberts1Gillian Whalley2Michael J. A. Williams3Sean Coffey4Department of Medicine – HeartOtago, Dunedin School of Medicine, University of OtagoDepartment of Physiology – HeartOtago, School of Biomedical Sciences, University of OtagoDepartment of Medicine – HeartOtago, Dunedin School of Medicine, University of OtagoDepartment of Medicine – HeartOtago, Dunedin School of Medicine, University of OtagoDepartment of Medicine – HeartOtago, Dunedin School of Medicine, University of OtagoAbstract Myocardial pathology results in significant morbidity and mortality, whether due to primary cardiomyopathic processes or secondary to other conditions such as ischemic heart disease. Cardiac imaging techniques characterise the underlying tissue directly, by assessing a signal from the tissue itself, or indirectly, by inferring tissue characteristics from global or regional function. Cardiac magnetic resonance imaging is currently the most investigated imaging modality for tissue characterisation, but, due to its accessibility, advanced echocardiography represents an attractive alternative. Speckle tracking echocardiography (STE) is a reproducible technique used to assess myocardial deformation at both segmental and global levels. Since distinct myocardial pathologies affect deformation differently, information about the underlying tissue can be inferred by STE. In this review, the current available studies correlating STE deformation parameters with underlying tissue characteristics in humans are examined, with separate emphasis on global and segmental analysis. The current knowledge is placed in the context of integrated backscatter and the future of echocardiographic based tissue characterisation is discussed. The use of these imaging techniques to more precisely phenotype myocardial pathology more precisely will allow the design of translational cardiac research studies and, potentially, tailored management strategies.http://link.springer.com/article/10.1186/s12947-019-0176-9EchocardiographyStrainSpeckle trackingFibrosisMyocardial histology
collection DOAJ
language English
format Article
sources DOAJ
author Mohammed A. Moharram
Regis R. Lamberts
Gillian Whalley
Michael J. A. Williams
Sean Coffey
spellingShingle Mohammed A. Moharram
Regis R. Lamberts
Gillian Whalley
Michael J. A. Williams
Sean Coffey
Myocardial tissue characterisation using echocardiographic deformation imaging
Cardiovascular Ultrasound
Echocardiography
Strain
Speckle tracking
Fibrosis
Myocardial histology
author_facet Mohammed A. Moharram
Regis R. Lamberts
Gillian Whalley
Michael J. A. Williams
Sean Coffey
author_sort Mohammed A. Moharram
title Myocardial tissue characterisation using echocardiographic deformation imaging
title_short Myocardial tissue characterisation using echocardiographic deformation imaging
title_full Myocardial tissue characterisation using echocardiographic deformation imaging
title_fullStr Myocardial tissue characterisation using echocardiographic deformation imaging
title_full_unstemmed Myocardial tissue characterisation using echocardiographic deformation imaging
title_sort myocardial tissue characterisation using echocardiographic deformation imaging
publisher BMC
series Cardiovascular Ultrasound
issn 1476-7120
publishDate 2019-11-01
description Abstract Myocardial pathology results in significant morbidity and mortality, whether due to primary cardiomyopathic processes or secondary to other conditions such as ischemic heart disease. Cardiac imaging techniques characterise the underlying tissue directly, by assessing a signal from the tissue itself, or indirectly, by inferring tissue characteristics from global or regional function. Cardiac magnetic resonance imaging is currently the most investigated imaging modality for tissue characterisation, but, due to its accessibility, advanced echocardiography represents an attractive alternative. Speckle tracking echocardiography (STE) is a reproducible technique used to assess myocardial deformation at both segmental and global levels. Since distinct myocardial pathologies affect deformation differently, information about the underlying tissue can be inferred by STE. In this review, the current available studies correlating STE deformation parameters with underlying tissue characteristics in humans are examined, with separate emphasis on global and segmental analysis. The current knowledge is placed in the context of integrated backscatter and the future of echocardiographic based tissue characterisation is discussed. The use of these imaging techniques to more precisely phenotype myocardial pathology more precisely will allow the design of translational cardiac research studies and, potentially, tailored management strategies.
topic Echocardiography
Strain
Speckle tracking
Fibrosis
Myocardial histology
url http://link.springer.com/article/10.1186/s12947-019-0176-9
work_keys_str_mv AT mohammedamoharram myocardialtissuecharacterisationusingechocardiographicdeformationimaging
AT regisrlamberts myocardialtissuecharacterisationusingechocardiographicdeformationimaging
AT gillianwhalley myocardialtissuecharacterisationusingechocardiographicdeformationimaging
AT michaeljawilliams myocardialtissuecharacterisationusingechocardiographicdeformationimaging
AT seancoffey myocardialtissuecharacterisationusingechocardiographicdeformationimaging
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