Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates
Abstract Background Klebsiella pneumoniae is a leading cause of hospital-associated (HA) infections. It has been reported that gastrointestinal colonization (GI) is likely to be a common and significant reservoir for the transmission and infections of K. pneumoniae in both adults and neonates. Howev...
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doaj-b8cdd850801f4ac0b90be8ff3e5fd82f2021-01-17T12:20:46ZengBMCBMC Microbiology1471-21802021-01-0121111110.1186/s12866-020-02073-2Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonatesChun-mei Chen0Min Wang1Xian-ping Li2Peng-ling Li3Jing-jing Tian4Kan Zhang5Can Luo6Department of Laboratory Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, Jiangxi Cancer HospitalDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South UniversityAbstract Background Klebsiella pneumoniae is a leading cause of hospital-associated (HA) infections. It has been reported that gastrointestinal colonization (GI) is likely to be a common and significant reservoir for the transmission and infections of K. pneumoniae in both adults and neonates. However, the homologous relationship between clinically isolated extraintestinal and enteral K. pneumoniae in neonates hasn’t been characterized yet. Results Forty-three isolates from 21 neonatal patients were collected in this study. The proportion of carbapenem resistance was 62.8%. There were 12 patients (12/21, 57.4%) whose antibiotic resistance phenotypes, genotypes, and ST types (STs) were concordant. Six sequence types were detected using MLST, with ST37 and ST54 being the dominant types. The results of MLST were consist with the results of PFGE. Conclusions These data showed that there might be a close homologous relationship between extraintestinal K. pneumoniae (EXKP) and enteral K. pneumoniae (EKP) in neonates, indicating that the K. pneumoniae from the GI tract is possibly to be a significant reservoir for causing extraintestinal infections.https://doi.org/10.1186/s12866-020-02073-2Klebsiella pneumoniaeGastrointestinal colonizationMultiple locus sequence typingEndogenic infectionAntibiotic resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chun-mei Chen Min Wang Xian-ping Li Peng-ling Li Jing-jing Tian Kan Zhang Can Luo |
spellingShingle |
Chun-mei Chen Min Wang Xian-ping Li Peng-ling Li Jing-jing Tian Kan Zhang Can Luo Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates BMC Microbiology Klebsiella pneumoniae Gastrointestinal colonization Multiple locus sequence typing Endogenic infection Antibiotic resistance |
author_facet |
Chun-mei Chen Min Wang Xian-ping Li Peng-ling Li Jing-jing Tian Kan Zhang Can Luo |
author_sort |
Chun-mei Chen |
title |
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates |
title_short |
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates |
title_full |
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates |
title_fullStr |
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates |
title_full_unstemmed |
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates |
title_sort |
homology analysis between clinically isolated extraintestinal and enteral klebsiella pneumoniae among neonates |
publisher |
BMC |
series |
BMC Microbiology |
issn |
1471-2180 |
publishDate |
2021-01-01 |
description |
Abstract Background Klebsiella pneumoniae is a leading cause of hospital-associated (HA) infections. It has been reported that gastrointestinal colonization (GI) is likely to be a common and significant reservoir for the transmission and infections of K. pneumoniae in both adults and neonates. However, the homologous relationship between clinically isolated extraintestinal and enteral K. pneumoniae in neonates hasn’t been characterized yet. Results Forty-three isolates from 21 neonatal patients were collected in this study. The proportion of carbapenem resistance was 62.8%. There were 12 patients (12/21, 57.4%) whose antibiotic resistance phenotypes, genotypes, and ST types (STs) were concordant. Six sequence types were detected using MLST, with ST37 and ST54 being the dominant types. The results of MLST were consist with the results of PFGE. Conclusions These data showed that there might be a close homologous relationship between extraintestinal K. pneumoniae (EXKP) and enteral K. pneumoniae (EKP) in neonates, indicating that the K. pneumoniae from the GI tract is possibly to be a significant reservoir for causing extraintestinal infections. |
topic |
Klebsiella pneumoniae Gastrointestinal colonization Multiple locus sequence typing Endogenic infection Antibiotic resistance |
url |
https://doi.org/10.1186/s12866-020-02073-2 |
work_keys_str_mv |
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