Fishing Pluripotency Mechanisms In Vivo
<p>To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave <i>in vivo </i>in their natural environment. It is particularly important to study the roles and interactions of the different proteins involv...
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doaj-b8e134b4c41d4df3acdacb6772f882822020-11-24T21:30:41ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882011-01-0174410417Fishing Pluripotency Mechanisms In VivoAna V. Sánchez-Sánchez, Esther Camp, José L. Mullor<p>To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave <i>in vivo </i>in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency <i>in vivo</i>. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.</p>http://www.biolsci.org/v07p0410.htm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana V. Sánchez-Sánchez, Esther Camp, José L. Mullor |
spellingShingle |
Ana V. Sánchez-Sánchez, Esther Camp, José L. Mullor Fishing Pluripotency Mechanisms In Vivo International Journal of Biological Sciences |
author_facet |
Ana V. Sánchez-Sánchez, Esther Camp, José L. Mullor |
author_sort |
Ana V. Sánchez-Sánchez, Esther Camp, José L. Mullor |
title |
Fishing Pluripotency Mechanisms In Vivo |
title_short |
Fishing Pluripotency Mechanisms In Vivo |
title_full |
Fishing Pluripotency Mechanisms In Vivo |
title_fullStr |
Fishing Pluripotency Mechanisms In Vivo |
title_full_unstemmed |
Fishing Pluripotency Mechanisms In Vivo |
title_sort |
fishing pluripotency mechanisms in vivo |
publisher |
Ivyspring International Publisher |
series |
International Journal of Biological Sciences |
issn |
1449-2288 |
publishDate |
2011-01-01 |
description |
<p>To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave <i>in vivo </i>in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency <i>in vivo</i>. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.</p> |
url |
http://www.biolsci.org/v07p0410.htm |
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