Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when it is dysregulated. In this review, we introduce recent advances for cellular senescence and inflammaging, the underlyi...

Full description

Bibliographic Details
Main Authors:	Xinghui Sun, Mark W. Feinberg
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Physiology
Subjects:	cellular senescence vascular endothelium long noncoding RNAs DNA damage SASP anti-senescent therapies
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2021.693067/full

Similar Items

Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity
by: Xiao Cheng, et al.
Published: (2021-04-01)

Is cellular senescence involved in cystic fibrosis?
by: Valentino Bezzerri, et al.
Published: (2019-02-01)

SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
by: Claudio A. Valenzuela, et al.
Published: (2019-10-01)

The Jekyll and Hyde of Cellular Senescence in Cancer
by: Dilara Demirci, et al.
Published: (2021-01-01)

Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro
by: Whitney Venturini, et al.
Published: (2020-05-01)

Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
by: Anthony M. Battram, et al.
Published: (2020-06-01)

Epigenetic Basis of Cellular Senescence and Its Implications in Aging
by: Timothy Nacarelli, et al.
Published: (2017-11-01)

Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice
by: Adam D. Hudgins, et al.
Published: (2018-02-01)

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence
by: Liao C, et al.
Published: (2020-12-01)

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
by: Ruchi Kumari, et al.
Published: (2021-03-01)

Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
by: Rohit Sharma, et al.
Published: (2020-05-01)

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification
by: Estella Zuccolo, et al.
Published: (2020-06-01)

Rôle et régulation de l'haptoglobine adipocytaire au cours du vieillissement
by: Astre, Gwendoline
Published: (2018)

Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies
by: Yao Wang, et al.
Published: (2021-03-01)

DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses
by: Kazuhiro Hitomi, et al.
Published: (2020-05-01)

The Premature Senescence in Breast Cancer Treatment Strategy
by: Małgorzata Milczarek
Published: (2020-07-01)

Targeting senescent cells in translational medicine
by: Marta Paez‐Ribes, et al.
Published: (2019-12-01)

The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced Inflammation
by: Jorge Morales-Valencia, et al.
Published: (2021-09-01)

Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
by: Zhengqi Qiu, et al.
Published: (2021-01-01)

Flavonoids in Skin Senescence Prevention and Treatment
by: Anna Domaszewska-Szostek, et al.
Published: (2021-06-01)

Oleuropein aglycone attenuates the pro-angiogenic phenotype of senescent fibroblasts: A functional study in endothelial cells
by: Francesca Margheri, et al.
Published: (2019-02-01)

The redox-senescence axis and its therapeutic targeting
by: Natalie YL. Ngoi, et al.
Published: (2021-09-01)

Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
by: Aisha Y. Madani, et al.
Published: (2021-02-01)

Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype
by: Rekha Jakhar, et al.
Published: (2019-05-01)

Identification d'un nouveau régulateur et d'une nouvelle fonction de la sénescence cellulaire
by: Ma, Xingjie
Published: (2018)

Ginsenoside Rg3 Prevents Oxidative Stress-Induced Astrocytic Senescence and Ameliorates Senescence Paracrine Effects on Glioblastoma
by: Jingang Hou, et al.
Published: (2017-09-01)

p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries
by: Gagandeep Kaur, et al.
Published: (2021-05-01)

Radiation-Induced Osteocyte Senescence Alters Bone Marrow Mesenchymal Stem Cell Differentiation Potential via Paracrine Signaling
by: Linshan Xu, et al.
Published: (2021-08-01)

Effect of menopausal hormone therapy on proteins associated with senescence and inflammation
by: Laura Faubion, et al.
Published: (2020-08-01)

Extracellular Vesicles as New Players in Cellular Senescence
by: Lorena Urbanelli, et al.
Published: (2016-08-01)

Modulation of the Senescence-Associated Inflammatory Phenotype in Human Fibroblasts by Olive Phenols
by: Beatrice Menicacci, et al.
Published: (2017-10-01)

Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
by: Rocío Mato-Basalo, et al.
Published: (2021-03-01)

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
by: Keng Siang Lee, et al.
Published: (2021-01-01)

Cancer Response to Therapy-Induced Senescence: A Matter of Dose and Timing
by: Maria Patrizia Mongiardi, et al.
Published: (2021-01-01)

Cellular Senescence in Renal and Urinary Tract Disorders
by: Yohan Santin, et al.
Published: (2020-11-01)

circGNAQ, a circular RNA enriched in vascular endothelium, inhibits endothelial cell senescence and atherosclerosis progression
by: Wei-peng Wu, et al.
Published: (2021-12-01)

Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies
by: Philipp Ernst, et al.
Published: (2021-02-01)

Residual Disease in Glioma Recurrence: A Dangerous Liaison with Senescence
by: Diana A. Putavet, et al.
Published: (2021-03-01)

Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence
by: Nicola Alessio, et al.
Published: (2020-03-01)

Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective
by: Victoria V. Lunyak, et al.
Published: (2017-12-01)