An assessment of morphological and pathological changes in paravertebral muscle degeneration using imaging and histological analysis: a cross-sectional study

• Main Authors: Ding-Chao Zhu, Jia-Hao Lin, Jia-Jing Xu, Qiang Guo, Yi-Han Wang, Chao Jiang, Hui-Gen Lu, Yao-Sen Wu
• Format: Article
• Language: English
• Published: BMC 2021-10-01
• Series: BMC Musculoskeletal Disorders
• Subjects: Low back pain; Paravertebral muscle; Magnetic resonance imaging; Fatty degeneration; Inflammatory
• Online Access: https://doi.org/10.1186/s12891-021-04734-3

Abstract Background The high signal of paravertebral muscle (PVM) on T2-weighted image (T2WI) is usually considered to be fatty degeneration. However, it is difficult to distinguish inflammatory edema from fatty degeneration on T2WI. The purpose of this study was to identify different types of PVM high signal in patients with low back pain (LBP) through magnetic resonance imaging (MRI) and histology. Methods Seventy patients with LBP underwent MRI. The signal change of multifidus both on T2WI and fat suppression image (FSI) was quantified by Image J. Furthermore, 25 of the 70 patients underwent surgery for degenerative lumbar disease and their multifidus were obtained during the operation. Histological analysis of the samples was performed by HE staining. Result Three types of PVM signal changes were identified from the MRI. Type 1 (n = 36) indicated fatty degeneration characterized by a high signal on T2WI and low signal on FSI. High signal on both T2WI and FSI, signifying type 2 meant inflammatory edema (n = 9). Type 3 (n = 25) showed high signal on T2WI and partial signal suppression on FSI, which meant a combination of fatty degeneration and inflammatory edema. Histological results were consistent with MRI. Among the 25 patients who underwent surgery, type 1 (n = 14) showed adipocytes infiltration, type 2 (n = 3) showed inflammatory cells infiltration and type 3 (n = 8) showed adipocytes and inflammatory cells infiltration. Conclusion From our results, there are three types of pathological changes in patients with PVM degeneration, which may help to decide on targeted treatments for LBP.